Gene: STAT5A

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
signal transducer and activator of transcription 5A
Ensembl
ENSG00000126561.16
Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
Annotation
Transcription factor

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-9.1e-20-8.9e-3--0.67-2.7e-25-6.4e-26--0.014-
protein-2e-9-9e-23-4.5e-4--4.9e-4-9.4e-19-3.8e-20-0.0027.6e-30.77

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC77.588.599.51010.51111.51212.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC21.52222.52323.52424.52525.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214161820222426280-2-4-6-8-10-12-14-16-18-20-22-24-26-28Pan-cancer01020304050607080901001100-10-20-30-40-50-60-70-80-90-100-110proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of STAT5A with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
ESTIMATE: ImmuneScore3.8e-816.2e-72.2e-160.0172.2e-162.2e-162.2e-162.2e-166.0e-52.8e-39e-7
HALLMARK_ALLOGRAFT_REJECTION1.6e-731.5e-62.2e-160.0246.6e-102.2e-162.2e-162.2e-161.9e-50.0062.1e-5
xcell: microenvironment score2.5e-701.4e-96.8e-70.0061.1e-92.2e-162.2e-162.2e-162.0e-50.0713.7e-8
ESTIMATE: ESTIMATEScore2.3e-692.6e-78e-80.0171.4e-92.2e-162.2e-162.2e-161.7e-46.1e-32.5e-8
xcell: immune score6e-661.6e-42.2e-160.0153e-102.2e-162.2e-162.2e-164.3e-30.0124.4e-4
HALLMARK_IL6_JAK_STAT3_SIGNALING4.1e-542.7e-72.2e-160.0561.6e-92.4e-72.2e-161.5e-92.7e-30.0973.0e-4
HALLMARK_COMPLEMENT4.2e-537.5e-72.2e-160.0971.1e-98.8e-82.2e-163.5e-80.0030.0552.8e-4
HALLMARK_IL2_STAT5_SIGNALING7.7e-516.1e-91.3e-50.0872.2e-168.5e-82.2e-164.5e-101.1e-30.222.2e-3
HALLMARK_INTERFERON_GAMMA_RESPONSE5.4e-509.9e-62.2e-160.0749.9e-81.7e-92.2e-166.6e-71.8e-30.337.1e-5
xcell: T cell CD8+ central memory9.1e-503.0e-43.6e-121.7e-30.137.8e-111.6e-152.7e-129.1e-49.8e-60.013
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of STAT5A

BRCA0.760.200.35proteinmRNASCNVmethylationCCRCC0.770.010.13-0.140.20-0.05proteinmRNASCNVmethylationCOAD0.590.030.04proteinmRNASCNVmethylationGBM0.64-0.10-0.12-0.20-0.070.32proteinmRNASCNVmethylationHNSCC0.72-0.24-0.21-0.34-0.280.01proteinmRNASCNVmethylationLSCC0.86-0.10-0.13-0.12-0.090.22proteinmRNASCNVmethylationLUAD0.74-0.030.08-0.080.080.13proteinmRNASCNVmethylationOV0.640.300.49proteinmRNASCNVmethylationPDAC0.370.10-0.03-0.000.180.16proteinmRNASCNVmethylationUCEC0.69-0.080.12-0.100.120.25proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of STAT5A and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.