Basic information

Full name
TGF-beta activated kinase 1 (MAP3K7) binding protein 2
Ensembl
ENSG00000055208.19
Summary
The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-0.009--3.7e-11--1.3e-6-0.1-0.087--0.47-
protein0.25--1.2e-7--6.4e-140.621.1e-6-4.6e-30.23-3.7e-3

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC99.51010.51111.51212.51313.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC1415161718192021222324log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC01234567890-1-2-3-4-5-6-7-8-9Pan-cancer024681012141618202224260-2-4-6-8-10-12-14-16-18-20-22-24-26proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of TAB2 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION5.3e-150.264.0e-4-0.374.3e-31.2e-64.1e-30.26.9e-39.2e-4
ESTIMATE: StromalScore9e-140.232.2e-5-0.0170.141.7e-50.0510.460.0454.5e-5
HALLMARK_KRAS_SIGNALING_UP1.4e-110.043.8e-3-3.7e-30.0183.7e-40.0380.530.120.025
PROGENy: TGFb1.3e-100.62.1e-3-0.110.0631.7e-60.620.320.0575.1e-5
HALLMARK_APICAL_JUNCTION1.5e-100.181.1e-3-0.370.264.6e-40.0250.470.0366.1e-5
HALLMARK_ANGIOGENESIS1.5e-100.250.083-0.183.8e-32.1e-50.0130.130.20.011
ESTIMATE: ESTIMATEScore4.7e-100.123.4e-5-6.9e-30.211.5e-30.0680.920.130.016
HALLMARK_UV_RESPONSE_DN1e-90.144.1e-3-0.0680.123.1e-50.30.140.150.014
HALLMARK_TGF_BETA_SIGNALING1.4e-90.190.07-1.8e-30.0251.3e-40.270.545.7e-30.17
xcell: microenvironment score1.1e-80.591.1e-6-1.7e-30.460.0340.410.660.0925.1e-3
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of TAB2

BRCA0.720.520.57proteinmRNASCNVmethylationCCRCC0.62-0.140.28-0.120.27-0.17proteinmRNASCNVmethylationCOAD0.31proteinmRNASCNVmethylationGBM0.55-0.150.30-0.250.39-0.25proteinmRNASCNVmethylationHNSCC0.650.020.390.070.370.07proteinmRNASCNVmethylationLSCC0.64-0.260.47-0.260.61-0.27proteinmRNASCNVmethylationLUAD0.51-0.020.290.030.54-0.04proteinmRNASCNVmethylationOV0.280.300.69proteinmRNASCNVmethylationPDAC0.460.230.160.070.51-0.02proteinmRNASCNVmethylationUCEC0.45-0.160.04-0.070.04-0.27proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of TAB2 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.