Basic information
- Full name
- TATA-box binding protein associated factor, RNA polymerase I subunit C
- Ensembl
- ENSG00000103168.16
- Summary
- Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011]
- Annotation
- Essential genes
Protein product
- ENST00000567759.5 Primary ENSP00000455265.1 (2 phosphosites)
- ENST00000566732.5
- ENST00000341690.10
- ENST00000541676.5
- ENST00000570117.5
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | -5.6e-8 | - | -8.2e-6 | - | - | 0.025 | -3.5e-4 | -1.5e-3 | - | -1.4e-3 | - |
protein | -0.057 | - | 0.2 | - | - | -0.64 | -0.3 | -0.023 | 0.71 | -0.78 | -9.3e-3 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of TAF1C with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
KINASE-PSP_CDK2 | 1.2e-8 | 0.2 | -0.33 | - | 0.11 | 0.46 | 0.017 | 0.013 | 2.6e-5 | 0.035 | 9.4e-4 | |
KINASE-PSP_CDK1 | 4.8e-7 | 0.59 | -0.85 | - | 0.086 | 0.018 | 0.019 | 0.064 | 0.035 | 0.32 | 7.6e-4 | |
PERT-PSP_NOCODAZOLE | 2.3e-6 | 0.015 | 0.56 | - | 0.49 | 0.32 | 0.18 | 0.087 | 1.2e-3 | 0.77 | 3.8e-3 | |
HALLMARK_MYC_TARGETS_V2 | 2.3e-5 | 0.82 | -0.77 | - | 0.078 | 0.92 | 1.3e-3 | 0.037 | 0.018 | 0.15 | 0.071 | |
xcell: T cell CD4+ Th1 | 2.7e-5 | 0.62 | 0.87 | - | 3.8e-3 | 0.66 | 2.2e-4 | 0.012 | -0.78 | 0.077 | 0.37 | |
HALLMARK_E2F_TARGETS | 3.5e-4 | 0.74 | -0.6 | - | 0.27 | 0.42 | 0.087 | 0.074 | 0.085 | 0.075 | 0.045 | |
HALLMARK_DNA_REPAIR | 4.0e-4 | 0.49 | 0.9 | - | 0.72 | 0.41 | 5.6e-3 | 0.31 | 0.19 | 0.035 | 0.16 | |
HALLMARK_G2M_CHECKPOINT | 1.7e-3 | 0.84 | -0.45 | - | 0.46 | -0.93 | 0.076 | 0.032 | 0.32 | 0.036 | 0.021 | |
chromosomal instability | 2.6e-3 | -0.053 | -0.97 | - | 0.029 | 0.41 | 0.42 | 0.099 | 0.042 | 0.023 | 0.22 | |
HALLMARK_SPERMATOGENESIS | 3.7e-3 | -0.8 | 0.59 | - | 0.9 | -0.9 | 0.029 | 0.11 | 9.2e-5 | 0.85 | 0.6 |
Cis-association
Associations between omics data of TAF1C
Trans-association
Associations of the protein abundance of TAF1C and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.