Basic information

Full name
TATA-box binding protein associated factor, RNA polymerase I subunit C
Ensembl
ENSG00000103168.16
Summary
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011]
Annotation
Essential genes

Protein product

Phosphosites on the primary protein product
Loading...

Tumor and normal comparison

Loading, please wait
Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-5.6e-8--8.2e-6--0.025-3.5e-4-1.5e-3--1.4e-3-
protein-0.057-0.2---0.64-0.3-0.0230.71-0.78-9.3e-3

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC6.577.588.599.51010.51111.512log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCGBMHNSCCLSCCLUADOVPDACUCEC151617181920212223log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0246810121416180-2-4-6-8-10-12-14-16-18Pan-cancer02468101214161820220-2-4-6-8-10-12-14-16-18-20-22proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of TAF1C with phenotypes and mutations

Loading, please wait
Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
KINASE-PSP_CDK21.2e-80.2-0.33-0.110.460.0170.0132.6e-50.0359.4e-4
KINASE-PSP_CDK14.8e-70.59-0.85-0.0860.0180.0190.0640.0350.327.6e-4
PERT-PSP_NOCODAZOLE2.3e-60.0150.56-0.490.320.180.0871.2e-30.773.8e-3
HALLMARK_MYC_TARGETS_V22.3e-50.82-0.77-0.0780.921.3e-30.0370.0180.150.071
xcell: T cell CD4+ Th12.7e-50.620.87-3.8e-30.662.2e-40.012-0.780.0770.37
HALLMARK_E2F_TARGETS3.5e-40.74-0.6-0.270.420.0870.0740.0850.0750.045
HALLMARK_DNA_REPAIR4.0e-40.490.9-0.720.415.6e-30.310.190.0350.16
HALLMARK_G2M_CHECKPOINT1.7e-30.84-0.45-0.46-0.930.0760.0320.320.0360.021
chromosomal instability2.6e-3-0.053-0.97-0.0290.410.420.0990.0420.0230.22
HALLMARK_SPERMATOGENESIS3.7e-3-0.80.59-0.9-0.90.0290.119.2e-50.850.6
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of TAF1C

BRCA0.180.220.36proteinmRNASCNVmethylationCCRCC-0.060.36-0.16-0.010.360.10proteinmRNASCNVmethylationCOAD0.43proteinmRNASCNVmethylationGBM0.10-0.130.12-0.160.26-0.14proteinmRNASCNVmethylationHNSCC-0.240.140.11-0.070.520.03proteinmRNASCNVmethylationLSCC0.240.080.230.110.610.15proteinmRNASCNVmethylationLUAD0.11-0.11-0.01-0.000.550.04proteinmRNASCNVmethylationOV-0.120.010.48proteinmRNASCNVmethylationPDAC-0.090.300.12-0.090.120.10proteinmRNASCNVmethylationUCEC0.05-0.05-0.07-0.170.22-0.06proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of TAF1C and the protein abundance of other genes

Loading, please wait
Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.