Gene: TAGLN

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
transgelin
Ensembl
ENSG00000149591.17
Summary
This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization. [provided by RefSeq, Aug 2017]

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-1.2e-10--0.14---0.49-3e-13-9.9e-12-0.063-
protein-2.8e-33--0.044-1.2e-23--2.2e-9-4.2e-19-3.6e-23-2.1e-59.2e-120.76

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC7891011121314151617log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC27282930313233343536log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0510152025300-5-10-15-20-25-30Pan-cancer0204060801001201401601800-20-40-60-80-100-120-140-160-180proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of TAGLN with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PROGENy: TGFb6.2e-1202.2e-162.2e-161.6e-51.5e-82.2e-162.2e-162.2e-162.2e-165.7e-102.2e-16
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION1.0e-1042.2e-163.5e-95.3e-52.2e-162.2e-162.2e-168.5e-82.2e-163.1e-52.2e-16
ESTIMATE: StromalScore9.8e-972.2e-162.2e-161.9e-62.1e-84.2e-82.2e-165.4e-72.2e-164.3e-52.2e-16
HALLMARK_MYOGENESIS1.7e-923.9e-122.2e-163.8e-82.2e-81.1e-55.8e-101.2e-62.2e-161.6e-102.2e-16
HALLMARK_UV_RESPONSE_DN6.8e-872.2e-166.3e-77.9e-43.2e-92.2e-162.2e-161.5e-62.2e-160.0182.2e-16
HALLMARK_APICAL_JUNCTION1.1e-692.2e-162.2e-160.0174.6e-79.7e-71.2e-59.8e-52.2e-161.9e-66.6e-9
xcell: stroma score9.5e-654e-92.4e-62.2e-161.0e-41.5e-32.4e-101.9e-54.6e-98.2e-71e-10
xcell: Cancer associated fibroblast7.1e-573e-77e-165e-12-0.962.9e-49.5e-123.1e-53.8e-71.1e-58.5e-10
HALLMARK_TGF_BETA_SIGNALING2.1e-482.2e-167.8e-54.8e-34.0e-60.033e-89.2e-62.7e-121.5e-42.1e-4
HALLMARK_ANGIOGENESIS4.2e-482.2e-164.6e-61.8e-46.8e-94.1e-55.5e-64.4e-42.2e-16-0.192.8e-6
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* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of TAGLN

BRCA0.810.300.34proteinmRNASCNVmethylationCCRCC0.86-0.040.03proteinmRNASCNVmethylationCOAD0.72-0.20-0.14proteinmRNASCNVmethylationGBM0.820.040.02proteinmRNASCNVmethylationHNSCC0.80-0.16-0.17proteinmRNASCNVmethylationLSCC0.830.080.21proteinmRNASCNVmethylationLUAD0.72-0.05-0.04proteinmRNASCNVmethylationOV0.880.080.10proteinmRNASCNVmethylationPDAC0.72-0.06-0.00proteinmRNASCNVmethylationUCEC0.830.100.11proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of TAGLN and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.