Basic information

Full name
TAP binding protein
Ensembl
ENSG00000231925.12
Summary
This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Protein product

  • ENST00000434618.7 Primary ENSP00000395701.2 (0 phosphosite)
  • ENST00000426633.6
  • ENST00000475304.5
  • ENST00000489157.5
  • ENST00000456592.3
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA3.9e-30-1.3e-28--1.6e-15-0.362.8e-8-0.07-
protein2.4e-60-5.2e-271.9e-16-1.1e-203.8e-108.8e-40.282.8e-100.29

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC7.588.599.51010.51111.51212.51313.51414.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC23.52424.52525.52626.52727.52828.529log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC024681012141618200-2-4-6-8-10-12-14-16-18-20Pan-cancer01020304050607080901001100-10-20-30-40-50-60-70-80-90-100-110proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of TAPBP with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_INTERFERON_ALPHA_RESPONSE5.4e-1162.2e-162.2e-162.2e-165.2e-102.2e-162.2e-162.2e-163.1e-73.2e-42.2e-16
HALLMARK_INTERFERON_GAMMA_RESPONSE7.4e-992.2e-169.1e-102.2e-166.6e-92.2e-162.2e-166.6e-103.9e-82.0e-51.6e-9
PROGENy: JAK-STAT3.5e-941.1e-102.2e-162.2e-163.3e-82.2e-162.2e-164.5e-98.6e-72.2e-45.8e-9
HALLMARK_ALLOGRAFT_REJECTION3.8e-672.2e-163.3e-61.6e-85.7e-32.2e-162.2e-165.5e-62.1e-52.2e-45.0e-6
HALLMARK_IL6_JAK_STAT3_SIGNALING1.8e-552.2e-168.2e-42.2e-76.2e-32.2e-166.9e-105.3e-47.5e-57.0e-51.3e-5
cibersort: Macrophage M13e-524.8e-141.4e-51.9e-60.0181.1e-101.8e-115.9e-98.3e-70.218.6e-5
ESTIMATE: ImmuneScore7.4e-512.2e-164.7e-63.2e-50.0332.2e-161.3e-92.8e-49.6e-43.4e-32.6e-5
xcell: Plasmacytoid dendritic cell8.2e-497.2e-190.381.5e-30.419.6e-202.3e-172.2e-49.4e-50.0071.5e-6
xcell: Myeloid dendritic cell activated7.8e-454.7e-148.7e-49.3e-42.8e-51e-127.7e-89.2e-51.1e-40.131.9e-5
HALLMARK_INFLAMMATORY_RESPONSE4.3e-422.2e-160.081.8e-40.0122.2e-163.7e-63.2e-37.7e-48.8e-51.9e-4
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of TAPBP

BRCA0.410.260.18proteinmRNASCNVmethylationCCRCC0.500.190.060.190.09-0.02proteinmRNASCNVmethylationCOAD0.410.180.38proteinmRNASCNVmethylationGBM0.520.050.09-0.170.190.10proteinmRNASCNVmethylationHNSCC0.620.380.150.250.15-0.05proteinmRNASCNVmethylationLSCC0.680.360.130.400.23-0.06proteinmRNASCNVmethylationLUAD0.590.250.170.120.31-0.24proteinmRNASCNVmethylationOV0.360.220.36proteinmRNASCNVmethylationPDAC0.44-0.070.28-0.140.43-0.22proteinmRNASCNVmethylationUCEC0.520.210.180.300.20-0.00proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of TAPBP and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.