Basic information

Full name
tec protein tyrosine kinase
Ensembl
ENSG00000135605.13
Summary
The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008]
Annotation
Druggable target (Tier T4) Protein Kinase

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-3.1e-25--0.49---1.3e-17-2.6e-27-4.6e-7-0.059-
protein-0.29-3.7e-7-0.027--8.1e-3--1.8e-11-0.655.6e-4

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2345678910111213log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLUADOVPDACUCEC13141516171819202122232425log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0510152025300-5-10-15-20-25-30Pan-cancer024681012141618202224260-2-4-6-8-10-12-14-16-18-20-22-24-26proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of TEC with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_COMPLEMENT5.6e-59.7e-50.027-0.720.340.051-3.4e-40.980.004-2.2e-3
HALLMARK_IL2_STAT5_SIGNALING8.7e-51.4e-40.0420.590.20.11-5.7e-3-0.624.5e-4-1.2e-3
HALLMARK_INFLAMMATORY_RESPONSE1.3e-41.1e-39.6e-30.730.250.047-0.013-0.831.2e-3-9.4e-4
xcell: Macrophage2.8e-45.2e-30.0130.840.460.19-5.4e-30.970.07-0.2
xcell: T cell regulatory (Tregs)4.7e-4-0.850.0530.750.0230.058-0.190.210.062-0.86
HALLMARK_IL6_JAK_STAT3_SIGNALING5.2e-42.7e-30.0580.730.20.046-0.012-0.456.5e-4-9.9e-4
HALLMARK_TNFA_SIGNALING_VIA_NFKB7.5e-40.0070.0290.640.30.21-0.0230.735.5e-4-3.5e-4
HALLMARK_APOPTOSIS8.9e-42.5e-40.0130.840.350.24-0.120.850.008-3.8e-3
HALLMARK_INTERFERON_GAMMA_RESPONSE1.3e-30.0360.130.40.320.32-0.0190.944.9e-3-0.045
HALLMARK_INTERFERON_ALPHA_RESPONSE1.4e-30.110.340.120.080.57-0.0890.574.7e-3-0.055
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of TEC

BRCA0.160.030.17proteinmRNASCNVmethylationCCRCC0.42-0.040.15-0.240.140.16proteinmRNASCNVmethylationCOAD0.25-0.000.44proteinmRNASCNVmethylationGBM0.190.070.22-0.660.020.16proteinmRNASCNVmethylationHNSCC0.22-0.04-0.04-0.150.28-0.02proteinmRNASCNVmethylationLSCC-0.110.33-0.09proteinmRNASCNVmethylationLUAD0.48-0.150.13-0.300.26-0.16proteinmRNASCNVmethylationOV0.16-0.020.36proteinmRNASCNVmethylationPDAC0.42-0.000.160.110.400.02proteinmRNASCNVmethylationUCEC0.72-0.130.07-0.020.100.01proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of TEC and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.