Basic information

Full name
TGFB induced factor homeobox 1
Ensembl
ENSG00000177426.21
Summary
The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]
Annotation
Transcription factor

Protein product

  • ENST00000330513.9 Primary ENSP00000327959.5 (16 phosphosites)
  • ENST00000618001.4
  • ENST00000343820.10
  • ENST00000407501.6
  • ENST00000472042.1
  • ENST00000405385.7
  • ENST00000401449.5
  • ENST00000548489.6
  • ENST00000400167.6
  • ENST00000345133.9
  • ENST00000551541.5
  • ENST00000551402.1
  • ENST00000577543.5
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA3.9e-26-0.73--3.2e-151.9e-104.1e-4-3.6e-8-
protein0.19-----3.4e-12-0.05--0.019-0.95

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC7.588.599.51010.51111.51212.513log2(RSEM+1)tumornormal
Protein expression
BRCAGBMHNSCCLSCCLUADOVPDACUCEC14151617181920212223log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC01234567891011120-1-2-3-4-5-6-7-8-9-10-11-12Pan-cancer0246810121416180-2-4-6-8-10-12-14-16-18proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of TGIF1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Tumor Purity (WGS)5.4e-5----0.647.9e-80.094-0.990.13
KINASE-PSP_CDK12.6e-30.25---0.0890.0150.14--0.460.17
HALLMARK_WNT_BETA_CATENIN_SIGNALING4.8e-31.4e-3---0.670.460.068-0.480.99
HALLMARK_DNA_REPAIR7.2e-30.11---0.374.2e-40.063--0.3-0.79
APC mutation0.013---------0.013
KEAP1 mutation0.027-----0.027----
Tumor Purity (ABSOLUTE)0.029-0.83----0.594.0e-60.16--0.60.55
chromosomal instability0.0330.044----0.382.8e-60.49--0.24-0.9
KINASE-PSP_JNK1/MAPK80.035---------0.035
KINASE-PSP_ERK2/MAPK10.0550.53---0.120.630.21-0.490.94
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of TGIF1

BRCA0.420.170.20proteinmRNASCNVmethylationCCRCC-0.160.280.04proteinmRNASCNVmethylationCOAD0.32proteinmRNASCNVmethylationGBM-0.190.23-0.09proteinmRNASCNVmethylationHNSCC0.10-0.490.180.050.540.07proteinmRNASCNVmethylationLSCC0.32-0.120.16-0.160.54-0.15proteinmRNASCNVmethylationLUAD0.60-0.160.31-0.040.56-0.04proteinmRNASCNVmethylationOV0.56proteinmRNASCNVmethylationPDAC0.20-0.220.160.140.63-0.07proteinmRNASCNVmethylationUCEC0.27-0.060.060.050.130.03proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of TGIF1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.