Basic information

Full name
tight junction protein 3
Ensembl
ENSG00000105289.15
Summary
The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1. [provided by RefSeq, May 2012]

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-7e-11--1.4e-28---1.2e-17-9.4e-122.7e-13-4.9e-6-
protein-5.9e-26--5.2e-30-4.1e-5--2.9e-21-3.3e-29-0.062-4.5e-73.2e-7

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678910111213log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADPDACUCEC161718192021222324252627log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC01234567891011120-1-2-3-4-5-6-7-8-9-10-11-12Pan-cancer02468101214161820222426280-2-4-6-8-10-12-14-16-18-20-22-24-26-28proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of TJP3 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_BILE_ACID_METABOLISM1.7e-106.6e-40.140.015-0.270.0884.5e-53.4e-6-0.290.14
HALLMARK_FATTY_ACID_METABOLISM5.3e-81.2e-30.223.5e-3-0.0340.590.133.4e-4-0.0554.8e-4
PROGENy: Androgen1.3e-76.8e-30.44-0.31-0.362.2e-43.1e-43.1e-5-0.0220.59
HALLMARK_PEROXISOME3e-76.0e-40.980.34-0.660.166.1e-42.4e-3-0.0710.086
HALLMARK_ANDROGEN_RESPONSE6e-78.5e-30.96-0.17-0.261.2e-46.0e-60.16-0.0641.6e-3
HALLMARK_ESTROGEN_RESPONSE_EARLY1.0e-61.4e-7-0.58-0.8-0.0940.0189.2e-50.023-0.160.055
HALLMARK_ESTROGEN_RESPONSE_LATE6.2e-67.9e-7-0.330.29-0.150.0252.3e-30.61-0.118.7e-3
PTEN mutation1.4e-5---------1.4e-5
PROGENy: p537.1e-50.290.220.180.190.44-0.210.034-8.6e-36.7e-3
HALLMARK_HEME_METABOLISM3.1e-40.170.0250.049-3.9e-30.431.3e-31.9e-4-0.44-0.72
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of TJP3

BRCA0.690.080.03proteinmRNASCNVmethylationCCRCC0.040.070.090.010.150.06proteinmRNASCNVmethylationCOAD0.570.170.20proteinmRNASCNVmethylationGBM0.250.170.030.170.240.24proteinmRNASCNVmethylationHNSCC0.560.160.170.080.070.16proteinmRNASCNVmethylationLSCC0.830.07-0.020.13-0.130.06proteinmRNASCNVmethylationLUAD0.780.050.20-0.010.270.04proteinmRNASCNVmethylationOV0.33proteinmRNASCNVmethylationPDAC0.690.320.160.130.34-0.05proteinmRNASCNVmethylationUCEC0.79-0.030.14-0.010.130.06proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of TJP3 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.