Basic information

Full name
troponin T3, fast skeletal type
Ensembl
ENSG00000130595.19
Summary
The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009]

Protein product

  • ENST00000397301.5 Primary ENSP00000380468.1 (4 phosphosites)
  • ENST00000446240.1
  • ENST00000641225.1
  • ENST00000381563.8
  • ENST00000278317.11
  • ENST00000381589.7
  • ENST00000641119.1
  • ENST00000381558.6
  • ENST00000641787.1
  • ENST00000381579.7
  • ENST00000344578.8
  • ENST00000381557.6
  • ENST00000397304.6
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-1.8e-30-0.15---7.6e-5-1.9e-12-7e-28--2.5e-7-
protein-1.5e-28-----5.8e-4-1.1e-20-1e-14-0.094--

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC024681012141618log2(RSEM+1)tumornormal
Protein expression
BRCAHNSCCLSCCLUADOV182022242628303234log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC051015202530350-5-10-15-20-25-30-35Pan-cancer051015202530354045500-5-10-15-20-25-30-35-40-45-50proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of TNNT3 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_MYOGENESIS7.8e-70.56---2.2e-160.22-0.990.3--
HALLMARK_APICAL_JUNCTION1.8e-60.89---2.2e-160.24-0.690.12--
xcell: Endothelial cell1.2e-40.6---8.9e-80.730.350.14--
ESTIMATE: StromalScore3.9e-40.8---2.2e-160.71-0.160.61--
KINASE-PSP_PAK14.9e-4----9.5e-40.26-0.11--
HALLMARK_IL2_STAT5_SIGNALING1.3e-30.064---1.4e-5-0.930.780.41--
HALLMARK_KRAS_SIGNALING_UP1.7e-30.57---1.0e-40.350.540.32--
HALLMARK_P53_PATHWAY1.8e-30.25---0.20.260.0220.26--
HALLMARK_COMPLEMENT2.8e-30.089---6.8e-50.65-0.760.39--
HALLMARK_IL6_JAK_STAT3_SIGNALING4.4e-30.018---2.3e-5-0.91-0.320.38--
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of TNNT3

BRCA0.090.190.15proteinmRNASCNVmethylationCCRCC-0.09proteinmRNASCNVmethylationCOAD0.13proteinmRNASCNVmethylationGBM-0.01proteinmRNASCNVmethylationHNSCC0.640.130.08proteinmRNASCNVmethylationLSCC-0.00-0.110.12proteinmRNASCNVmethylationLUAD0.260.220.12proteinmRNASCNVmethylationOV-0.11-0.15-0.00proteinmRNASCNVmethylationPDAC-0.09proteinmRNASCNVmethylationUCEC-0.09proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of TNNT3 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.