Gene: TYROBP

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
transmembrane immune signaling adaptor TYROBP
Ensembl
ENSG00000011600.12
Summary
This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]
Annotation
Receptor

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-4.4e-4-4.4e-29--6.9e-9-1.9e-29-2.8e-22--0.37-
protein6.1e-12-6.3e-300.044-5.6e-21-6.8e-20-4.4e-30.11.2e-70.42

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC66.577.588.599.51010.51111.51212.513log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC181920212223242526log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC051015202530354045500-5-10-15-20-25-30-35-40-45-50Pan-cancer0204060801001201401601802002202402602803000-20-40-60-80-100-120-140-160-180-200-220-240-260-280-300proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of TYROBP with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: Macrophage2.4e-881.1e-62.2e-167.3e-32.2e-161.5e-103e-226.6e-85e-81.9e-81.1e-10
HALLMARK_INFLAMMATORY_RESPONSE4.2e-731.9e-51.4e-92.3e-52.2e-162.1e-92.2e-162.3e-42.3e-43.6e-62.2e-16
xcell: Macrophage M14.3e-732.9e-64.8e-160.0282.2e-166.7e-102.2e-167.0e-65e-73.1e-49.6e-11
ESTIMATE: ImmuneScore4.4e-676.2e-42.2e-160.0072.2e-165.5e-92.2e-161.0e-41.9e-40.0212.2e-16
HALLMARK_IL6_JAK_STAT3_SIGNALING1.4e-661.3e-32.2e-167.3e-45.4e-112.3e-82.2e-166.0e-52.9e-44.7e-42.2e-16
HALLMARK_COMPLEMENT1e-641.6e-42.2e-161.1e-42.2e-161.7e-82.2e-161.1e-36.9e-56.1e-35.6e-9
HALLMARK_ALLOGRAFT_REJECTION5.6e-619.5e-52.2e-165.4e-32.2e-169.6e-92.2e-161.5e-45.4e-30.032.9e-10
xcell: Monocyte1.8e-590.0383.8e-110.0181.3e-92.9e-81.3e-193.7e-55.1e-64.6e-92.5e-7
xcell: immune score5e-594.0e-42.2e-160.222.2e-161.1e-82.2e-163.6e-42.7e-55.3e-49.5e-7
PROGENy: TNFa6.2e-531.1e-54.1e-53.5e-51.4e-74.4e-52.2e-160.0473.5e-33e-72.2e-16
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of TYROBP

BRCA0.40-0.040.08proteinmRNASCNVmethylationCCRCC0.740.020.14proteinmRNASCNVmethylationCOAD0.25-0.030.04proteinmRNASCNVmethylationGBM0.72-0.18-0.18proteinmRNASCNVmethylationHNSCC0.67-0.13-0.09proteinmRNASCNVmethylationLSCC0.75-0.06-0.06proteinmRNASCNVmethylationLUAD0.460.060.03proteinmRNASCNVmethylationOV0.520.06-0.05proteinmRNASCNVmethylationPDAC0.46-0.14-0.08proteinmRNASCNVmethylationUCEC0.660.040.08proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of TYROBP and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.