Basic information

Full name
UDP glucuronosyltransferase family 1 member A8
Ensembl
ENSG00000242366.3
Summary
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids. [provided by RefSeq, Jul 2008]

Protein product

  • ENST00000373450.4 Primary ENSP00000362549.4 (0 phosphosite)
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA5.5e-3-0.51---1.2e-141.9e-107.9e-3-2.2e-5-
protein-2.3e-3-----2.3e-3-----

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678910111213log2(RSEM+1)tumornormal
Protein expression
CCRCCCOADHNSCCLSCC1313.51414.51515.51616.51717.51818.51919.520log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0123456780-1-2-3-4-5-6-7-8Pan-cancer0.00.51.01.52.02.53.03.54.04.55.05.56.06.57.00.0-0.5-1.0-1.5-2.0-2.5-3.0-3.5-4.0-4.5-5.0-5.5-6.0-6.5-7.0proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of UGT1A8 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
SBS13 (APOBEC activity)0.016----0.0130.36----
HALLMARK_GLYCOLYSIS0.042----0.570.021----
cibersort: Neutrophil0.048-----0.954.2e-3----
cibersort: Macrophage M20.062----0.290.11----
PROGENy: Hypoxia0.066----0.810.018----
KINASE-PSP_PKCA/PRKCA0.074----0.910.016----
PROGENy: VEGF0.087----0.720.039----
PERT-P100-DIA_STAUROSPORINE0.097----0.930.024----
PERT-PSP_PHORBOL_ESTER0.1----0.0980.51----
SBS2 (APOBEC activity)0.1----0.110.47----
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of UGT1A8

BRCA0.15proteinmRNASCNVmethylationCCRCC0.16proteinmRNASCNVmethylationCOAD0.12proteinmRNASCNVmethylationGBM-0.02proteinmRNASCNVmethylationHNSCC-0.05-0.510.07proteinmRNASCNVmethylationLSCC0.710.240.15proteinmRNASCNVmethylationLUAD-0.06proteinmRNASCNVmethylationOV0.08proteinmRNASCNVmethylationPDAC0.10proteinmRNASCNVmethylationUCEC0.02proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of UGT1A8 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.