Gene: UNC5C

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
unc-5 netrin receptor C
Ensembl
ENSG00000182168.15
Summary
This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008]
Annotation
Receptor

Protein product

Phosphosites on the primary protein product
100200300400500600700800900Residue numberNumberThThDeatZU5 dImmunUPA domaMRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQTAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNTSGAVTPQDDLSEFTSKLSPQMTQSLLENEALSLKNQSLARQTDPSCTAFGSFNSLGGHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQTLLTPVVSCGPPGALLTRPVVLTMHHCADPNTEDWKILLKNQAAQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGHSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEILHLERQMGGQLLEEPKALHFKGSTHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHVWSGSQRNLHCTFTLERFSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPANTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQY010203040506070

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-2.1e-23--5.2e-16--6.7e-3-5.4e-19-2.3e-16-0.83-
protein0.15-----0.15----

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC12345678910111213log2(RSEM+1)tumornormal
Protein expression
COADGBMLSCCLUADPDACUCEC13141516171819202122log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0246810121416182022240-2-4-6-8-10-12-14-16-18-20-22-24Pan-cancer05101520253035404550550-5-10-15-20-25-30-35-40-45-50-55proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of UNC5C with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PROGENy: TNFa3.2e-8----0.44-0.032--2.2e-16-
PERT-PSP_ANTI_CD33.1e-4---0.036-0.1--0.012-
HALLMARK_INFLAMMATORY_RESPONSE1.9e-3----0.5-0.011--4.7e-4-
HALLMARK_TNFA_SIGNALING_VIA_NFKB3.9e-3----0.38-0.04--1.3e-4-
HALLMARK_HEME_METABOLISM4.1e-3---0.057-0.17--0.088-
PROGENy: NFkB5.2e-3----0.49-0.09--1.3e-4-
HALLMARK_INTERFERON_GAMMA_RESPONSE5.9e-3----0.98-0.19--4.7e-4-
PROGENy: JAK-STAT7.1e-3---0.27-0.18--0.028-
xcell: T cell NK7.9e-3---0.23-0.068--0.11-
xcell: Macrophage M28.4e-3---0.43-0.35--4.5e-3-
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of UNC5C

BRCA0.06proteinmRNASCNVmethylationCCRCC0.130.17-0.00proteinmRNASCNVmethylationCOAD-0.21proteinmRNASCNVmethylationGBM0.620.030.040.110.16-0.17proteinmRNASCNVmethylationHNSCC-0.070.130.04proteinmRNASCNVmethylationLSCC0.43-0.180.190.180.370.23proteinmRNASCNVmethylationLUAD0.090.160.03proteinmRNASCNVmethylationOV0.04proteinmRNASCNVmethylationPDAC-0.18-0.01-0.100.140.03proteinmRNASCNVmethylationUCEC-0.010.26-0.01proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of UNC5C and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
AMPD3 4.9e-12---0.2-0.013--2.2e-16-
PDGFD 2.5e-11---2.2e-16-0.016--0.35-
FBXO6 2.1e-10---0.024-0.59--2.2e-16-
SPTBN4 4.8e-9---9.1e-6-1.2e-4----
HCK 1e-8----0.29-5.7e-3--2.2e-16-
RNASE3 1.2e-8----0.91-0.078--2.2e-16-
RAPGEF2 2.3e-8---2.1e-6-3.3e-4--0.18-
SLC14A1 3.6e-7---1.0e-5-5.3e-3----
DAAM1 5e-7---4.0e-4-1.2e-3--0.054-
DNAJC12 7.1e-7---4.5e-4-6.4e-5--0.28-
Showing 1 to 10 of 19700 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.