Basic information
- Full name
- WD repeat containing antisense to TP53
- Ensembl
- ENSG00000141499.17
- Summary
- This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]
Protein product
- ENST00000396463.7 Primary ENSP00000379727.3 (18 phosphosites)
- ENST00000316024.9
- ENST00000457584.6
- ENST00000431639.6
- ENST00000534050.5
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 4.1e-14 | - | 1.1e-6 | - | - | 1.9e-14 | 2.4e-7 | 0.12 | - | -0.019 | - |
protein | 0.71 | - | 2.8e-8 | - | - | 0.41 | -0.03 | -4.7e-4 | 0.065 | -0.46 | -0.41 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of WRAP53 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
Tumor Purity (WGS) | 3.5e-12 | - | 1.7e-3 | - | 7.9e-4 | 0.83 | 1.0e-6 | 0.037 | - | 0.092 | 2.4e-3 | |
chromosomal instability | 7.1e-10 | 7.4e-3 | 0.41 | -0.78 | 3.3e-3 | 0.12 | 2.4e-10 | 0.089 | 0.77 | 9.4e-3 | 0.39 | |
xcell: T cell CD4+ Th1 | 6.6e-8 | 1.1e-4 | 0.043 | -0.89 | 0.011 | -0.96 | 8.2e-4 | -0.9 | 0.084 | 0.11 | 0.022 | |
Tumor Purity (ABSOLUTE) | 6e-7 | 0.022 | 4.4e-3 | -0.94 | 1.5e-3 | 0.38 | 4.3e-6 | 0.2 | -0.99 | -0.37 | 0.091 | |
HALLMARK_SPERMATOGENESIS | 2.3e-4 | 0.022 | -0.42 | 0.23 | 0.89 | 3.1e-3 | 5.6e-10 | 0.57 | -0.12 | -0.12 | 0.031 | |
xcell: T cell CD4+ central memory | 2.6e-4 | 9.6e-3 | 0.33 | 0.046 | 0.22 | -0.72 | 0.036 | -0.22 | 0.2 | 0.04 | 0.38 | |
HALLMARK_E2F_TARGETS | 9.3e-4 | 0.023 | 0.95 | 0.23 | 0.45 | 0.013 | 4.7e-7 | -0.45 | -0.013 | 0.63 | 0.16 | |
HALLMARK_G2M_CHECKPOINT | 1.1e-3 | 0.18 | 0.83 | 0.16 | 0.55 | 0.023 | 4e-7 | -0.44 | -0.079 | 0.54 | 0.17 | |
HALLMARK_MYC_TARGETS_V2 | 1.1e-3 | 1.7e-3 | 0.69 | -0.73 | 0.23 | 0.64 | 6.1e-5 | -0.43 | 0.95 | 0.26 | 0.27 | |
KINASE-PSP_CK2A1/CSNK2A1 | 1.4e-3 | -1 | -4.3e-3 | 0.48 | 0.014 | 0.011 | 8.2e-3 | 0.52 | 0.39 | 0.79 | 5.1e-3 |
Cis-association
Associations between omics data of WRAP53
Trans-association
Associations of the protein abundance of WRAP53 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.