Basic information

Full name
WD repeat containing antisense to TP53
Ensembl
ENSG00000141499.17
Summary
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA4.1e-14-1.1e-6--1.9e-142.4e-70.12--0.019-
protein0.71-2.8e-8--0.41-0.03-4.7e-40.065-0.46-0.41

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC55.566.577.588.599.510log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC16171819202122232425log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer051015202530354045500-5-10-15-20-25-30-35-40-45-50proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of WRAP53 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Tumor Purity (WGS)3.5e-12-1.7e-3-7.9e-40.831.0e-60.037-0.0922.4e-3
chromosomal instability7.1e-107.4e-30.41-0.783.3e-30.122.4e-100.0890.779.4e-30.39
xcell: T cell CD4+ Th16.6e-81.1e-40.043-0.890.011-0.968.2e-4-0.90.0840.110.022
Tumor Purity (ABSOLUTE)6e-70.0224.4e-3-0.941.5e-30.384.3e-60.2-0.99-0.370.091
HALLMARK_SPERMATOGENESIS2.3e-40.022-0.420.230.893.1e-35.6e-100.57-0.12-0.120.031
xcell: T cell CD4+ central memory2.6e-49.6e-30.330.0460.22-0.720.036-0.220.20.040.38
HALLMARK_E2F_TARGETS9.3e-40.0230.950.230.450.0134.7e-7-0.45-0.0130.630.16
HALLMARK_G2M_CHECKPOINT1.1e-30.180.830.160.550.0234e-7-0.44-0.0790.540.17
HALLMARK_MYC_TARGETS_V21.1e-31.7e-30.69-0.730.230.646.1e-5-0.430.950.260.27
KINASE-PSP_CK2A1/CSNK2A11.4e-3-1-4.3e-30.480.0140.0118.2e-30.520.390.795.1e-3
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of WRAP53

BRCA0.410.240.29proteinmRNASCNVmethylationCCRCC0.150.010.03-0.110.30-0.08proteinmRNASCNVmethylationCOAD0.330.400.61proteinmRNASCNVmethylationGBM0.31-0.060.030.150.200.09proteinmRNASCNVmethylationHNSCC0.330.050.070.070.370.08proteinmRNASCNVmethylationLSCC0.55-0.040.15-0.130.44-0.16proteinmRNASCNVmethylationLUAD0.18-0.010.08-0.070.440.01proteinmRNASCNVmethylationOV0.230.140.68proteinmRNASCNVmethylationPDAC0.070.07-0.07-0.090.32-0.20proteinmRNASCNVmethylationUCEC0.31-0.170.11-0.070.220.16proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of WRAP53 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.