Basic information

Full name
X-prolyl aminopeptidase 3
Ensembl
ENSG00000196236.13
Summary
The protein encoded by this gene belongs to the family of X-pro-aminopeptidases that utilize a metal cofactor, and remove the N-terminal amino acid from peptides with a proline residue in the penultimate position. This protein has been shown to localize to the mitochondria of renal cells, and have a role in ciliary function. Mutations in this gene are associated with nephronophthisis-like nephropathy-1. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene, however, expression of some of these isoforms in vivo is not known.[provided by RefSeq, Mar 2011]

Protein product

  • ENST00000357137.9 Primary ENSP00000349658.4 (0 phosphosite)
  • ENST00000614001.1
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA5e-9--9.7e-19--5.4e-98.2e-241.1e-12--0.082-
protein2.3e-7--3.8e-233.9e-15-0.0241.4e-184.4e-85.8e-3-7.7e-120.011

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC77.588.599.51010.51111.51212.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC20.52121.52222.52323.52424.52525.526log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0123456780-1-2-3-4-5-6-7-8Pan-cancer012345678910111213140-1-2-3-4-5-6-7-8-9-10-11-12-13-14proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of XPNPEP3 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_GLYCOLYSIS1.2e-130.080.0110.990.0224.3e-70.0078.1e-50.0850.692.4e-3
HALLMARK_FATTY_ACID_METABOLISM4.7e-110.0360.023-0.640.242.1e-51.7e-40.240.270.0162.7e-3
HALLMARK_OXIDATIVE_PHOSPHORYLATION8.6e-100.250.0540.90.96.3e-48.2e-30.0170.0140.0471.5e-3
HALLMARK_MYC_TARGETS_V21.4e-90.530.0730.0850.581.2e-40.0173.4e-30.330.0460.021
HALLMARK_MTORC1_SIGNALING3e-90.140.270.780.291.6e-64.3e-37.8e-30.230.478.5e-3
HALLMARK_PEROXISOME9.5e-92.9e-43.8e-30.0850.597.5e-38.2e-3-0.0430.120.113.5e-3
HALLMARK_CHOLESTEROL_HOMEOSTASIS3.7e-70.110.130.350.741.4e-63.1e-30.270.290.290.49
PERT-PSP_NOCODAZOLE1.5e-60.320.240.45-0.432.3e-30.0950.0150.0990.0540.017
KINASE-PSP_CDK23.9e-60.640.430.13-0.0920.0448.1e-30.0250.130.010.011
Tumor Purity (ABSOLUTE)8.1e-60.660.140.0320.840.0020.0560.030.0340.960.61
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of XPNPEP3

BRCA0.690.420.49proteinmRNASCNVmethylationCCRCC0.28-0.110.18-0.180.110.05proteinmRNASCNVmethylationCOAD0.520.250.38proteinmRNASCNVmethylationGBM0.410.100.400.160.330.06proteinmRNASCNVmethylationHNSCC0.73-0.000.510.050.46-0.06proteinmRNASCNVmethylationLSCC0.760.110.55-0.000.490.19proteinmRNASCNVmethylationLUAD0.37-0.100.200.050.450.01proteinmRNASCNVmethylationOV0.470.400.60proteinmRNASCNVmethylationPDAC0.39-0.090.18-0.010.440.19proteinmRNASCNVmethylationUCEC0.54-0.030.21-0.060.420.06proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of XPNPEP3 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.