Basic information

Full name
zinc finger MYM-type containing 2
Ensembl
ENSG00000121741.16
Summary
The protein encoded by this gene is a zinc finger protein that may act as a transcription factor. The encoded protein may be part of a BHC histone deacetylase complex. Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
Annotation
Cancer driver (TSG)

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA0.13--0.35---9.3e-71.2e-60.016-0.05-
protein3.6e-61-0.363.3e-20-3.8e-67e-321.1e-215.7e-44.5e-70.035

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC99.51010.51111.51212.51313.51414.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC21.52222.52323.52424.52525.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer051015202530350-5-10-15-20-25-30-35proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of ZMYM2 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Tumor Purity (WGS)2.3e-24-0.23-1.2e-113.7e-53.1e-110.04-0.0326.8e-5
chromosomal instability1.1e-200.002-0.81.2e-70.0193.3e-92.2e-160.0870.0230.590.71
Tumor Purity (ABSOLUTE)1.7e-190.0680.0672.0e-43.1e-82.1e-45.3e-90.360.250.594.5e-4
xcell: T cell CD4+ Th11.5e-171.1e-30.0425.0e-48.6e-90.281.1e-40.0840.0990.185.5e-3
HALLMARK_SPERMATOGENESIS1.3e-168.1e-30.4-0.0272.0e-51.9e-102.2e-161.1e-30.093-0.190.016
HALLMARK_G2M_CHECKPOINT9.9e-155.3e-30.28-0.871.2e-63.1e-62.4e-90.0310.80.530.024
HALLMARK_WNT_BETA_CATENIN_SIGNALING9.1e-140.57.3e-41.3e-95.3e-30.160.190.690.0713.8e-40.027
HALLMARK_E2F_TARGETS2.3e-131.1e-30.33-0.691.7e-61.0e-51e-90.13-0.640.440.026
HALLMARK_MYC_TARGETS_V26.1e-132.5e-3-0.640.110.0113.6e-32.6e-105.6e-30.150.580.036
KINASE-PSP_CDK23.4e-120.0120.270.125.4e-71.8e-62.7e-50.031-0.86-0.710.21
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of ZMYM2

BRCA0.390.250.57proteinmRNASCNVmethylationCCRCC0.38-0.100.17-0.050.20-0.30proteinmRNASCNVmethylationCOAD0.380.340.59proteinmRNASCNVmethylationGBM0.56-0.120.32-0.180.53-0.23proteinmRNASCNVmethylationHNSCC0.64-0.200.16-0.120.55-0.01proteinmRNASCNVmethylationLSCC0.71-0.110.14-0.110.46-0.02proteinmRNASCNVmethylationLUAD0.79-0.130.44-0.150.62-0.23proteinmRNASCNVmethylationOV0.520.400.66proteinmRNASCNVmethylationPDAC0.49-0.050.360.040.61-0.06proteinmRNASCNVmethylationUCEC0.44-0.180.020.070.250.05proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of ZMYM2 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.