Gene: ZNF75D

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
zinc finger protein 75D
Ensembl
ENSG00000186376.15
Summary
This gene encodes a protein that likely functions as a transcription factor. The protein, which belongs to the ZNF75 family, includes an N-terminal SCAN domain, a KRAB box, and five C2H2-type zinc finger motifs. Another functional gene belonging to this family is located on chromosome 16, while pseudogenes have been identified on chromosomes 11 and 12. Alternative splicing results in multiple transcripts variants. [provided by RefSeq, Jun 2010]
Annotation
Transcription factor

Protein product

  • ENST00000370766.8 Primary ENSP00000359802.3 (0 phosphosite)
  • ENST00000370764.1
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-0.019-6.5e-15---8.1e-5-1.8e-185.2e-4--1.5e-4-
protein-----------

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC77.588.599.51010.51111.51212.5log2(RSEM+1)tumornormal
Protein expression

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678910110-1-2-3-4-5-6-7-8-9-10-11Pan-cancer02468101214161820220-2-4-6-8-10-12-14-16-18-20-22proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of ZNF75D with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: T cell CD8+ central memory-----------
xcell: T cell CD8+ effector memory-----------
xcell: Class-switched memory B cell-----------
xcell: Common lymphoid progenitor-----------
xcell: Common myeloid progenitor-----------
xcell: Myeloid dendritic cell-----------
xcell: Endothelial cell-----------
xcell: Eosinophil-----------
xcell: Cancer associated fibroblast-----------
xcell: Granulocyte-monocyte progenitor-----------
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of ZNF75D

BRCA0.33proteinmRNASCNVmethylationCCRCC-0.07-0.07-0.11proteinmRNASCNVmethylationCOAD0.54proteinmRNASCNVmethylationGBM-0.030.290.07proteinmRNASCNVmethylationHNSCC-0.130.06-0.13proteinmRNASCNVmethylationLSCC-0.130.14-0.39proteinmRNASCNVmethylationLUAD0.170.51-0.15proteinmRNASCNVmethylationOV0.44proteinmRNASCNVmethylationPDAC0.110.28-0.29proteinmRNASCNVmethylationUCEC0.160.230.27proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of ZNF75D and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.