CFTR: CF transmembrane conductance regulator
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1xmi chain A
1xmi chain B
1xmi chain C
1xmi chain D
1xmi chain E
1xmj chain A
2bbo chain A
2bbs chain A
2bbs chain B
2bbt chain A
2bbt chain B
2lob chain B
2pze chain A
2pze chain B
2pzf chain A
2pzf chain B
2pzg chain A
2pzg chain B
3gd7 chain A
3gd7 chain B
3gd7 chain C
3gd7 chain D
3isw chain C
4wz6 chain A
5d2d chain C
5d3e chain C
5d3e chain G
5d3e chain K
5d3f chain C
5tf7 chain A
5tf8 chain A
5tfa chain A
5tfb chain A
5tfc chain A
5tfd chain A
5tff chain A
5tfg chain A
5tfi chain A
5tfj chain A
5tgk chain A
5uak chain A
6gjq chain A
6gjq chain C
6gjq chain E
6gjq chain G
6gjs chain A
6gju chain A
6gk4 chain A
6gk4 chain D
6gkd chain A
6gkd chain F
6gkd chain I
6gkd chain L
6gkd chain O
6gkd chain R
6hep chain E
6hep chain F
6msm chain A
6o1v chain A
6o2p chain A
6uk1 chain A
6uk1 chain B
6uk1 chain C
6uk1 chain D
6wbs chain A
6wbs chain B
6ze1 chain A
7qi1 chain E
7qi1 chain F
7sv7 chain A
7svd chain A
7svr chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S42 SDIYQIPS VDSADNL 2 17 - - 4 4 4 5 - - - - - - - - - - - - - - S45 YQIPSVDS ADNLSEK 2 117 - - - - 16 19 - - - - - - - - - - 58 24 - - S422 NNNNRKTS NGDDSLF 3 54 - - 3 3 8 10 - - - - - - - - - - 20 10 - - S427 KTSNGDDS LFFSNFS 1 9 - - - - 4 5 - - - - - - - - - - - - - - S660 FSAERRNS ILTETLH 7 671 - - 27 26 63 54 - - - - 64 57 85 76 34 9 105 44 18 9 S670 TETLHRFS LEGDAPV 2 43 - - - - - - - - - - - - 5 4 - - 23 11 - - S678 LEGDAPVS WTETKKQ 1 6 - - - - - - - - - - - - - - - - 4 2 - - S700 FGEKRKNS ILNPINS 5 326 - - - - 47 42 - - - - - - 4 4 23 5 99 40 48 14 S707 SILNPINS IRKFSIV 1 133 - - - - - - - - - - - - - - - - 93 40 - - S737 EPLERRLS LVPDSEQ 7 841 - - 7 7 86 93 - - - - 63 59 102 94 73 18 105 44 72 18
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S42 SDIYQIPS VDSADNL - - - - - - - - - - - S45 YQIPSVDS ADNLSEK -9.4e-10 - - - - - - - - -9.4e-10 - S422 NNNNRKTS NGDDSLF -5.3e-3 - - - - - - - - -5.3e-3 - S427 KTSNGDDS LFFSNFS - - - - - - - - - - - S660 FSAERRNS ILTETLH -6.2e-9 - -0.21 -0.2 - - -4.8e-15 -3.0e-4 - 0.33 - S670 TETLHRFS LEGDAPV -0.065 - - - - - - - - -0.065 - S678 LEGDAPVS WTETKKQ - - - - - - - - - - - S700 FGEKRKNS ILNPINS -2.4e-12 - - -3.1e-5 - - - - - -1.8e-8 -0.019 S707 SILNPINS IRKFSIV -1.1e-14 - - - - - - - - -1.1e-14 - S737 EPLERRLS LVPDSEQ -8e-22 - - -0.094 - - -8.4e-15 -5.8e-6 -0.46 -3e-17 -0.72
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S42
S45
S422
S427
S660
S670
S678
S700
S707
S737
S753
S756
S768
S795
S813
S1196
S1442
S1455
S1456
S1460
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S42 S45 S422 S427 S660 S670 S678 S700 S707 S737 S756 S768 S795 S813 S1196 S1442 S1455 S1456 S1460 protein RNA SCNV methylation CCRCC S42 S45 S422 S427 S660 S670 S678 S700 S707 S737 S756 S768 S795 S813 S1196 S1442 S1455 S1456 S1460 protein RNA SCNV methylation COAD S42 S45 S422 S427 S660 S670 S678 S700 S707 S737 S756 S768 S795 S813 S1196 S1442 S1455 S1456 S1460 protein RNA SCNV methylation GBM S42 S45 S422 S427 S660 S670 S678 S700 S707 S737 S756 S768 S795 S813 S1196 S1442 S1455 S1456 S1460 protein RNA SCNV methylation HNSCC S42 S45 S422 S427 S660 S670 S678 S700 S707 S737 S756 S768 S795 S813 S1196 S1442 S1455 S1456 S1460 protein RNA SCNV methylation LSCC S42 S45 S422 S427 S660 S670 S678 S700 S707 S737 S756 S768 S795 S813 S1196 S1442 S1455 S1456 S1460 protein RNA SCNV methylation LUAD S42 S45 S422 S427 S660 S670 S678 S700 S707 S737 S756 S768 S795 S813 S1196 S1442 S1455 S1456 S1460 protein RNA SCNV methylation OV S42 S45 S422 S427 S660 S670 S678 S700 S707 S737 S756 S768 S795 S813 S1196 S1442 S1455 S1456 S1460 protein RNA SCNV methylation PDAC S42 S45 S422 S427 S660 S670 S678 S700 S707 S737 S756 S768 S795 S813 S1196 S1442 S1455 S1456 S1460 protein RNA SCNV methylation UCEC S42 S45 S422 S427 S660 S670 S678 S700 S707 S737 S756 S768 S795 S813 S1196 S1442 S1455 S1456 S1460 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S42
S45
S422
S427
S660
S670
S678
S700
S707
S737
S753
S756
S768
S795
S813
S1196
S1442
S1455
S1456
S1460
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S42
S45
S422
S427
S660
S670
S678
S700
S707
S737
S753
S756
S768
S795
S813
S1196
S1442
S1455
S1456
S1460
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.