Protein: ENSP00000005178

PDK4:: pyruvate dehydrogenase kinase 4

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

Loading, please wait

				BRCA		CCRCC		COAD		GBM		HNSCC		LSCC		LUAD		OV		PDAC		UCEC
Site	Sequence	Cohorts	Total	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N
S13	FVLRSAGSLNGAGLV	2	35	-	-	-	-	-	-	-	-	-	-	-	-	9	8	-	-	14	4	-	-

Showing 1 to 1 of 1 rows

Tumor and normal comparison

Loading, please wait

Site	Sequence	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
S13	FVLRSAGSLNGAGLV	-	-	-	-	-	-	-	-	-	-	-

Showing 1 to 1 of 1 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

Loading, please wait

			Signed p-values
Phenotype	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
xcell: Hematopoietic stem cell	S13	5.4e-4	-	-	-	-	-	-	-	-	5.4e-4	-
HALLMARK_KRAS_SIGNALING_DN	S13	0.01	-	-	-	-	-	-	-	-	0.01	-
PROGENy: Androgen	S13	0.016	-	-	-	-	-	-	-	-	0.016	-
cibersort: T cell CD4+ memory resting	S13	0.037	-	-	-	-	-	-	-	-	0.037	-
HALLMARK_ESTROGEN_RESPONSE_EARLY	S13	0.048	-	-	-	-	-	-	-	-	0.048	-
HALLMARK_MYOGENESIS	S13	0.084	-	-	-	-	-	-	-	-	0.084	-
cibersort: Mast cell activated	S13	0.09	-	-	-	-	-	-	-	-	0.09	-
PROGENy: p53	S13	0.1	-	-	-	-	-	-	-	-	0.1	-
xcell: T cell CD4+ central memory	S13	0.1	-	-	-	-	-	-	-	-	0.1	-
cibersort: B cell memory	S13	0.1	-	-	-	-	-	-	-	-	0.1	-

Showing 1 to 10 of 258 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

Loading, please wait

			Signed p-values
Kinase	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
CAMK1	S13	3.8e-3	-	-	-	-	-	-	-	-	3.8e-3	-
PXK	S13	0.011	-	-	-	-	-	-	-	-	0.011	-
DCLK1	S13	0.012	-	-	-	-	-	-	-	-	0.012	-
PDGFRA	S13	0.019	-	-	-	-	-	-	-	-	0.019	-
STK33	S13	0.022	-	-	-	-	-	-	-	-	0.022	-
CAMK2B	S13	0.026	-	-	-	-	-	-	-	-	0.026	-
MYLK	S13	0.026	-	-	-	-	-	-	-	-	0.026	-
KALRN	S13	0.027	-	-	-	-	-	-	-	-	0.028	-
WNK2	S13	0.029	-	-	-	-	-	-	-	-	0.029	-
MST1R	S13	0.032	-	-	-	-	-	-	-	-	0.032	-

Showing 1 to 10 of 538 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

Loading, please wait

			Signed p-values
Phosphatase	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
PFKFB3	S13	-2.1e-3	-	-	-	-	-	-	-	-	-2.1e-3	-
PLPP6	S13	-2.5e-3	-	-	-	-	-	-	-	-	-2.5e-3	-
PTPN11	S13	-3.5e-3	-	-	-	-	-	-	-	-	-3.5e-3	-
PTPN6	S13	-5.6e-3	-	-	-	-	-	-	-	-	-5.6e-3	-
TIMM50	S13	-8.4e-3	-	-	-	-	-	-	-	-	-8.4e-3	-
FIG4	S13	-8.9e-3	-	-	-	-	-	-	-	-	-8.9e-3	-
PTPN7	S13	-0.022	-	-	-	-	-	-	-	-	-0.022	-
PGAM5	S13	-0.024	-	-	-	-	-	-	-	-	-0.024	-
PTPN1	S13	-0.026	-	-	-	-	-	-	-	-	-0.026	-
ACP5	S13	-0.042	-	-	-	-	-	-	-	-	-0.042	-

Showing 1 to 10 of 240 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Protein: ENSP00000005178Gene: PDK4

Lollipop plot

Structure

Phosphosite detection coverage

Tumor and normal comparison

Phenotype and mutation association

Cis-association

Kinase association

Phosphatase association

Protein: ENSP00000005178
Gene: PDK4