Protein: ENSP00000005257

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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				BRCA		CCRCC		COAD		GBM		HNSCC		LSCC		LUAD		OV		PDAC		UCEC
Site	Sequence	Cohorts	Total	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N
S11	NKPKGQNSLALHKVI	10	718	31	-	20	19	28	34	81	-	13	6	35	31	110	101	70	15	38	17	53	16
S138	LEDKRQVSVEEAKNR	2	22	-	-	-	-	-	-	9	-	-	-	-	-	-	-	-	-	9	4	-	-

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Tumor and normal comparison

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Site	Sequence	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
S11	NKPKGQNSLALHKVI	-2.0e-5	-	-0.13	0.012	-	-	-7.6e-8	-7.7e-14	0.32	-1	0.69
S138	LEDKRQVSVEEAKNR	-	-	-	-	-	-	-	-	-	-	-

Showing 1 to 2 of 2 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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			Signed p-values
Phenotype	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
HALLMARK_HYPOXIA	S11	9.1e-5	0.31	0.46	0.6	0.71	0.81	0.18	0.011	8.0e-4	0.18	0.36
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	S11	6.6e-4	0.12	0.11	0.42	0.77	0.49	0.28	0.17	1.6e-4	0.56	-0.32
HALLMARK_MYOGENESIS	S11	1.4e-3	1.8e-4	0.27	0.18	0.067	-0.83	-0.81	0.25	4.8e-5	-0.14	-0.22
HALLMARK_P53_PATHWAY	S11	2.9e-3	0.46	0.12	0.84	0.51	-0.63	0.037	-0.34	2.8e-4	0.14	0.62
SBS2 (APOBEC activity)	S11	4.5e-3	-0.57	-	-	-	2.2e-4	0.89	0.32	0.035	-	-
Clinical: Path_Stage_pT	S11	6.2e-3	-0.45	0.19	0.5	-	-	0.05	0.29	-	0.97	3.2e-3
HALLMARK_UV_RESPONSE_UP	S11	7.3e-3	-0.7	0.11	0.73	0.12	-0.81	0.77	0.029	0.017	0.96	0.47
HALLMARK_APICAL_JUNCTION	S11	8.1e-3	0.12	0.52	0.41	0.18	-0.62	0.31	0.51	6.2e-3	-0.39	0.33
PROGENy: VEGF	S11	0.009	-0.42	4.6e-3	0.51	-0.74	0.63	0.052	0.23	-0.83	8.5e-3	-0.89
PROGENy: Hypoxia	S11	9.7e-3	-0.97	0.33	0.38	0.74	-0.99	0.15	0.062	0.53	0.18	0.44

Showing 1 to 10 of 516 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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			Signed p-values
Kinase	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
PDGFRB	S11	1.0e-6	0.008	0.089	0.31	0.77	0.14	0.54	0.038	0.002	0.069	0.49
BMPR1B	S11	1.4e-5	0.021	-	-	0.016	-	-	-	-	-	5.3e-3
PTK7	S11	5.5e-5	0.11	6.3e-4	0.056	-0.007	0.23	0.33	0.24	0.007	0.26	0.18
TAOK1	S11	1.8e-4	-0.72	0.04	0.094	0.043	6.3e-3	0.054	0.67	0.12	0.58	-0.46
ACVR2A	S11	2.2e-4	-	-	-	7.1e-3	-	0.047	0.61	-	0.027	-
MAP4K4	S11	2.3e-4	0.27	0.19	0.04	0.69	0.25	0.15	0.53	0.5	0.03	0.5
CSNK1G2	S11	2.6e-4	-	-	-	0.34	-	0.026	0.27	-	0.045	0.06
INSR	S11	2.8e-4	0.41	0.35	0.26	0.021	0.52	0.85	0.18	0.16	0.65	0.024
TGFBR1	S11	3.6e-4	0.81	-	-	0.2	-	0.18	0.024	-0.7	0.15	1.2e-3
MARK3	S11	5.2e-4	0.4	-0.61	1	0.33	0.04	0.011	2.4e-3	0.37	-0.88	0.2

Showing 1 to 10 of 1076 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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			Signed p-values
Phosphatase	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
SSU72	S11	-1.5e-4	-0.005	0.43	-0.06	-0.076	-0.43	0.27	-0.027	-0.2	-0.5	-0.013
HDHD2	S11	-1.1e-3	0.24	-0.63	-0.82	0.94	-0.022	-0.073	-1.2e-3	0.64	-0.017	-0.11
NT5DC1	S11	-1.2e-3	-0.067	-0.63	-0.8	0.12	-0.55	-0.29	-4.6e-3	-0.011	-0.35	-0.22
ILKAP	S11	-2.6e-3	-0.014	0.85	-0.42	-4.3e-4	0.078	0.53	-0.12	-0.038	-0.17	-0.77
PTP4A2	S11	-5.4e-3	0.27	-0.47	-0.46	0.24	-0.55	-2.2e-3	-1.5e-3	-	-0.18	-0.31
ACP1	S11	-6.1e-3	0.48	0.64	0.87	-0.46	-0.16	-0.5	-1.5e-3	-0.032	-0.22	-0.5
PTPN4	S11	-9.3e-3	0.78	-	-	-0.37	-	-0.18	-0.49	-	-0.046	-0.084
NT5C	S11	-0.012	0.27	-0.73	0.62	0.64	-0.27	-0.56	-0.009	-0.66	-8.6e-3	-0.023
TAB1	S11	-0.013	-0.91	0.087	-	0.31	-0.32	-	-2.7e-3	-0.87	-0.055	-3.6e-4
UBLCP1	S11	-0.019	0.6	-0.2	-0.15	-0.063	-0.45	-0.81	-0.27	0.38	-0.82	-0.054

Showing 1 to 10 of 480 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Protein: ENSP00000005257
Gene: RALA

Lollipop plot

Structure

Phosphosite detection coverage

Tumor and normal comparison

Phenotype and mutation association

Cis-association

Kinase association

Phosphatase association

Protein: ENSP00000005257Gene: RALA

Lollipop plot

Structure

Phosphosite detection coverage

Tumor and normal comparison

Phenotype and mutation association

Cis-association

Kinase association

Phosphatase association

Protein: ENSP00000005257
Gene: RALA