DVL2: dishevelled segment polarity protein 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2rey chain A
3cbx chain A
3cbx chain B
3cby chain A
3cby chain B
3cbz chain A
3cc0 chain A
3cc0 chain B
3cc0 chain C
4wip chain A
4wip chain B
4wip chain C
5lnp chain A
5lnp chain B
5lnp chain C
5lnp chain D
5suy chain A
5suy chain B
5suy chain C
5suy chain D
5suz chain A
5suz chain B
6iw3 chain A
6jck chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
Y55 QRPAGAKY FFKSMDQ 1 6 6 - - - - - - - - - - - - - - - - - - - S59 GAKYFFKS MDQDFGV 1 6 6 - - - - - - - - - - - - - - - - - - - S142 SFHPNVSS SHENLEP 1 9 - - - - - - 9 - - - - - - - - - - - - - S143 FHPNVSSS HENLEPE 2 54 9 - - - - - 45 - - - - - - - - - - - - - T153 NLEPETET ESVVSLR 1 37 - - - - - - 37 - - - - - - - - - - - - - S158 TETESVVS LRRERPR 2 17 8 - - - - - 9 - - - - - - - - - - - - - S169 ERPRRRDS SEHGAGG 6 80 - - 8 8 4 2 9 - 20 12 - - - - 7 1 5 4 - - S170 RPRRRDSS EHGAGGH 5 178 - - 8 8 - - 18 - 20 12 - - - - 44 7 42 19 - - S211 ESTSLGDS DEEDTMS 6 200 8 - - - 4 5 71 - 23 13 35 32 - - - - - - 7 2 S252 PRLERTSS FSSVTDS 4 79 - - 17 8 - - 10 - - - 10 9 13 12 - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Y55 QRPAGAKY FFKSMDQ - - - - - - - - - - - S59 GAKYFFKS MDQDFGV - - - - - - - - - - - S142 SFHPNVSS SHENLEP - - - - - - - - - - - S143 FHPNVSSS HENLEPE - - - - - - - - - - - T153 NLEPETET ESVVSLR - - - - - - - - - - - S158 TETESVVS LRRERPR - - - - - - - - - - - S169 ERPRRRDS SEHGAGG 0.12 - - - - 0.12 - - - - - S170 RPRRRDSS EHGAGGH 0.078 - - - - 0.12 - - - 0.36 - S211 ESTSLGDS DEEDTMS -0.13 - - - - -0.85 -0.052 - - - - S252 PRLERTSS FSSVTDS - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
Y55
S59
S142
S143
T153
S158
S169
S170
S211
S252
S254
S255
S358
T364
S407
S418
T421
S614
S616
S618
S620
S622
S641
S648
S651
T715
S717
S720
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA Y55 S59 S142 S143 T153 S158 S169 S170 S211 S252 S254 S255 S358 T364 S407 S418 T421 S614 S616 S618 S620 S622 S641 S648 S651 T715 S717 S720 protein RNA SCNV methylation CCRCC Y55 S59 S142 S143 T153 S158 S169 S170 S211 S252 S254 S255 S358 T364 S407 S418 T421 S614 S616 S618 S620 S622 S641 S648 S651 T715 S717 S720 protein RNA SCNV methylation COAD Y55 S59 S142 S143 T153 S158 S169 S170 S211 S252 S254 S255 S358 T364 S407 S418 T421 S614 S616 S618 S620 S622 S641 S648 S651 T715 S717 S720 protein RNA SCNV methylation GBM Y55 S59 S142 S143 T153 S158 S169 S170 S211 S252 S254 S255 S358 T364 S407 S418 T421 S614 S616 S618 S620 S622 S641 S648 S651 T715 S717 S720 protein RNA SCNV methylation HNSCC Y55 S59 S142 S143 T153 S158 S169 S170 S211 S252 S254 S255 S358 T364 S407 S418 T421 S614 S616 S618 S620 S622 S641 S648 S651 T715 S717 S720 protein RNA SCNV methylation LSCC Y55 S59 S142 S143 T153 S158 S169 S170 S211 S252 S254 S255 S358 T364 S407 S418 T421 S614 S616 S618 S620 S622 S641 S648 S651 T715 S717 S720 protein RNA SCNV methylation LUAD Y55 S59 S142 S143 T153 S158 S169 S170 S211 S252 S254 S255 S358 T364 S407 S418 T421 S614 S616 S618 S620 S622 S641 S648 S651 T715 S717 S720 protein RNA SCNV methylation OV Y55 S59 S142 S143 T153 S158 S169 S170 S211 S252 S254 S255 S358 T364 S407 S418 T421 S614 S616 S618 S620 S622 S641 S648 S651 T715 S717 S720 protein RNA SCNV methylation PDAC Y55 S59 S142 S143 T153 S158 S169 S170 S211 S252 S254 S255 S358 T364 S407 S418 T421 S614 S616 S618 S620 S622 S641 S648 S651 T715 S717 S720 protein RNA SCNV methylation UCEC Y55 S59 S142 S143 T153 S158 S169 S170 S211 S252 S254 S255 S358 T364 S407 S418 T421 S614 S616 S618 S620 S622 S641 S648 S651 T715 S717 S720 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
Y55
S59
S142
S143
T153
S158
S169
S170
S211
S252
S254
S255
S358
T364
S407
S418
T421
S614
S616
S618
S620
S622
S641
S648
S651
T715
S717
S720
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
Y55
S59
S142
S143
T153
S158
S169
S170
S211
S252
S254
S255
S358
T364
S407
S418
T421
S614
S616
S618
S620
S622
S641
S648
S651
T715
S717
S720
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.