PPP5C: protein phosphatase 5 catalytic subunit
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1a17 chain A
1s95 chain A
1s95 chain B
1wao chain 1
1wao chain 2
1wao chain 3
1wao chain 4
2bug chain A
3h60 chain A
3h60 chain B
3h61 chain A
3h61 chain D
3h62 chain B
3h62 chain C
3h63 chain A
3h63 chain C
3h64 chain A
3h64 chain D
3h66 chain A
3h66 chain B
3h67 chain A
3h67 chain D
3h68 chain A
3h68 chain D
3h69 chain A
3h69 chain D
4zvz chain A
4zvz chain B
4zvz chain C
4zvz chain D
4zx2 chain A
5hpe chain A
5ui1 chain A
5ui1 chain B
5ui1 chain C
5ui1 chain D
5wg8 chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S189 EDGKVTIS FMKELMQ 1 9 - - - - - - 9 - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S189 EDGKVTIS FMKELMQ - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S189 protein RNA SCNV methylation CCRCC S189 protein RNA SCNV methylation COAD S189 protein RNA SCNV methylation GBM S189 protein RNA SCNV methylation HNSCC S189 protein RNA SCNV methylation LSCC S189 protein RNA SCNV methylation LUAD S189 protein RNA SCNV methylation OV S189 protein RNA SCNV methylation PDAC S189 protein RNA SCNV methylation UCEC S189 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S189
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
ACVR2A S189 - - - - - - - - - - - ACVR2B S189 - - - - - - - - - - - ABR S189 - - - - - - - - - - - ACVR1C S189 - - - - - - - - - - - ACVR1 S189 - - - - - - - - - - - ABL2 S189 - - - - - - - - - - - AATK S189 - - - - - - - - - - - AAK1 S189 - - - - - - - - - - - ABL1 S189 - - - - - - - - - - - ACVR1B S189 - - - - - - - - - - -
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S189
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
ALPI S189 - - - - - - - - - - - ALPL S189 - - - - - - - - - - - ACP5 S189 - - - - - - - - - - - ALPG S189 - - - - - - - - - - - ACP6 S189 - - - - - - - - - - - ACP4 S189 - - - - - - - - - - - ACP2 S189 - - - - - - - - - - - ACP1 S189 - - - - - - - - - - - ACP3 S189 - - - - - - - - - - - ACP7 S189 - - - - - - - - - - -
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.