Protein: ENSP00000013125
Gene: MAP4K5

LinkedOmicsKB © 2022-2023 Zhang Lab

MAP4K5:
mitogen-activated protein kinase kinase kinase kinase 5

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S174ATIAKRKSFIGTPYW8960105-1616--62-975510899110101--93394415
S323IIRHTIRSTNRNARA631635-----89---25231615--5324297
S335ARAERTASEINFDKL101489122-103809710099-975688811101017617105449518
S362RDEMGLSSDPNFMLQ341----512----45------132
S400PPKPRISSYPEDNFP7241----212436-54--5436784789
Y401PKPRISSYPEDNFPD738559-624954--9735325452--125--
S421TIKHCPDSESRAPQI36617-----------44392----
S433PQILRRQSSPSCGPV51508-----36-------51841384
S434QILRRQSSPSCGPVA1074284-2120343899-25165550333240857238918
S436LRRQSSPSCGPVAET7121--333254--535554--1046-
Showing 1 to 10 of 16 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S174ATIAKRKSFIGTPYW6.4e-8----9.1e-145.7e-3-0.15-3.1e-8-0.027
S323IIRHTIRSTNRNARA5e-9-----4.3e-3--6.1e-8-
S335ARAERTASEINFDKL0.18-1.9e-34.6e-3-5.9e-11-5.9e-3-7.8e-4-0.0287.8e-6-1.5e-6
S362RDEMGLSSDPNFMLQ-----------
S400PPKPRISSYPEDNFP-0.067---0.067-------
Y401PKPRISSYPEDNFPD-2.3e-3-8.3e-6----2.7e-14-0.035---
S421TIKHCPDSESRAPQI-----------
S433PQILRRQSSPSCGPV-----------
S434QILRRQSSPSCGPVA0.17-0.023-0.039--0.190.240.025-1.0e-4-0.01
S436LRRQSSPSCGPVAET0.021-0.021--------
Showing 1 to 10 of 16 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS174S323S335S362S400Y401S421S433S434S436T443S444S445Y837S845Y846proteinRNASCNVmethylationCCRCCS174S323S335S362S400Y401S421S433S434S436T443S444S445Y837S845Y846proteinRNASCNVmethylationCOADS174S323S335S362S400Y401S421S433S434S436T443S444S445Y837S845Y846proteinRNASCNVmethylationGBMS174S323S335S362S400Y401S421S433S434S436T443S444S445Y837S845Y846proteinRNASCNVmethylationHNSCCS174S323S335S362S400Y401S421S433S434S436T443S444S445Y837S845Y846proteinRNASCNVmethylationLSCCS174S323S335S362S400Y401S421S433S434S436T443S444S445Y837S845Y846proteinRNASCNVmethylationLUADS174S323S335S362S400Y401S421S433S434S436T443S444S445Y837S845Y846proteinRNASCNVmethylationOVS174S323S335S362S400Y401S421S433S434S436T443S444S445Y837S845Y846proteinRNASCNVmethylationPDACS174S323S335S362S400Y401S421S433S434S436T443S444S445Y837S845Y846proteinRNASCNVmethylationUCECS174S323S335S362S400Y401S421S433S434S436T443S444S445Y837S845Y846proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.