Protein: ENSP00000056217
Gene: ARHGEF5

LinkedOmicsKB © 2022-2023 Zhang Lab

ARHGEF5:
Rho guanine nucleotide exchange factor 5

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S184SGQTRYYSPCEEHPA85799---9593--16109845821984329518
T193CEEHPAETNQNEGSE3386---------54--194----
S199ETNQNEGSESGTIRQ690--4445----5543153--2414
S406ENEHHGPSMPALIAP19------------54------
S445ESRAEELSPAALSPS942329-20121413--32215853383221532619
S450ELSPAALSPSLEPIR10124386-9572797417-9755837410597711679309518
S517TPPRTPDSAPPSPAE73598-17162124--68395548----414513
S521TPDSAPPSPAEAYPI937415-21193528--536359454711523616
Y526PPSPAEAYPITPASV18----------44--------
T529PAEAYPITPASVSAR231----------44------194
Showing 1 to 10 of 57 rows
102550100
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S184SGQTRYYSPCEEHPA3.6e-3---0.75----5.0e-40.0150.8
T193CEEHPAETNQNEGSE-----------
S199ETNQNEGSESGTIRQ0.034---------0.034
S406ENEHHGPSMPALIAP-----------
S445ESRAEELSPAALSPS0.11-0.37---4.4e-47.9e-40.013---
S450ELSPAALSPSLEPIR-0.015-0.53-1e-7--2.8e-150.120.0260.848.1e-3-0.33
S517TPPRTPDSAPPSPAE-5.6e-5---4.6e-3--6.8e-70.098----0.057
S521TPDSAPPSPAEAYPI-0.89--0.45-0.1--0.29--0.41-0.069
Y526PPSPAEAYPITPASV-----------
T529PAEAYPITPASVSAR-----------
Showing 1 to 10 of 57 rows
102550100
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS184T193S199S406S445S450S517S521Y526T529S547S606S625S627Y641S652S657S662T735T816T896S897S908T912S915S917S920S926T929S935S936T938T939T971T972S978S983S1004S1011S1019S1044S1083S1093S1117S1119T1121S1125S1126S1136S1137S1139S1145S1162Y1370S1403S1405T1473proteinRNASCNVmethylationCCRCCS184T193S199S406S445S450S517S521Y526T529S547S606S625S627Y641S652S657S662T735T816T896S897S908T912S915S917S920S926T929S935S936T938T939T971T972S978S983S1004S1011S1019S1044S1083S1093S1117S1119T1121S1125S1126S1136S1137S1139S1145S1162Y1370S1403S1405T1473proteinRNASCNVmethylationCOADS184T193S199S406S445S450S517S521Y526T529S547S606S625S627Y641S652S657S662T735T816T896S897S908T912S915S917S920S926T929S935S936T938T939T971T972S978S983S1004S1011S1019S1044S1083S1093S1117S1119T1121S1125S1126S1136S1137S1139S1145S1162Y1370S1403S1405T1473proteinRNASCNVmethylationGBMS184T193S199S406S445S450S517S521Y526T529S547S606S625S627Y641S652S657S662T735T816T896S897S908T912S915S917S920S926T929S935S936T938T939T971T972S978S983S1004S1011S1019S1044S1083S1093S1117S1119T1121S1125S1126S1136S1137S1139S1145S1162Y1370S1403S1405T1473proteinRNASCNVmethylationHNSCCS184T193S199S406S445S450S517S521Y526T529S547S606S625S627Y641S652S657S662T735T816T896S897S908T912S915S917S920S926T929S935S936T938T939T971T972S978S983S1004S1011S1019S1044S1083S1093S1117S1119T1121S1125S1126S1136S1137S1139S1145S1162Y1370S1403S1405T1473proteinRNASCNVmethylationLSCCS184T193S199S406S445S450S517S521Y526T529S547S606S625S627Y641S652S657S662T735T816T896S897S908T912S915S917S920S926T929S935S936T938T939T971T972S978S983S1004S1011S1019S1044S1083S1093S1117S1119T1121S1125S1126S1136S1137S1139S1145S1162Y1370S1403S1405T1473proteinRNASCNVmethylationLUADS184T193S199S406S445S450S517S521Y526T529S547S606S625S627Y641S652S657S662T735T816T896S897S908T912S915S917S920S926T929S935S936T938T939T971T972S978S983S1004S1011S1019S1044S1083S1093S1117S1119T1121S1125S1126S1136S1137S1139S1145S1162Y1370S1403S1405T1473proteinRNASCNVmethylationOVS184T193S199S406S445S450S517S521Y526T529S547S606S625S627Y641S652S657S662T735T816T896S897S908T912S915S917S920S926T929S935S936T938T939T971T972S978S983S1004S1011S1019S1044S1083S1093S1117S1119T1121S1125S1126S1136S1137S1139S1145S1162Y1370S1403S1405T1473proteinRNASCNVmethylationPDACS184T193S199S406S445S450S517S521Y526T529S547S606S625S627Y641S652S657S662T735T816T896S897S908T912S915S917S920S926T929S935S936T938T939T971T972S978S983S1004S1011S1019S1044S1083S1093S1117S1119T1121S1125S1126S1136S1137S1139S1145S1162Y1370S1403S1405T1473proteinRNASCNVmethylationUCECS184T193S199S406S445S450S517S521Y526T529S547S606S625S627Y641S652S657S662T735T816T896S897S908T912S915S917S920S926T929S935S936T938T939T971T972S978S983S1004S1011S1019S1044S1083S1093S1117S1119T1121S1125S1126S1136S1137S1139S1145S1162Y1370S1403S1405T1473proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

Loading, please wait
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.