Protein: ENSP00000170447
Gene: MKRN2

LinkedOmicsKB © 2022-2023 Zhang Lab

MKRN2:
makorin ring finger protein 2

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S25EGSQCLFSHDLANSK19------9-------------
T49KGYCAYGTRCRYDHT82289-1212--64-106252398--74372
S96ASIVKTNSHEPGKRE238------9---1514--------
S115VLRDRNLSGMAERKT1072266-1515413936-503170655043411057255216
S128KTQPSMVSNPGSCSD215--42----63----------
S132SMVSNPGSCSDPQPS33116-44--------------52
S134VSNPGSCSDPQPSPE720657-323045--64--3029--324-
S139SCSDPQPSPEMKPHS10118862-5752535599-9756108998577215105449518
S365EKPRKQLSSQGTVRF7290------89-126544430533137015
S366KPRKQLSSQGTVRFF219----------54------10-
Showing 1 to 10 of 10 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S25EGSQCLFSHDLANSK-----------
T49KGYCAYGTRCRYDHT1.2e-6-----1.2e-6----
S96ASIVKTNSHEPGKRE-----------
S115VLRDRNLSGMAERKT9.7e-8--0.68--0.129.6e-72.4e-7-0.793.2e-40.061
S128KTQPSMVSNPGSCSD-----------
S132SMVSNPGSCSDPQPS-----------
S134VSNPGSCSDPQPSPE-1.3e-8--1.9e-7-----4.6e-3---
S139SCSDPQPSPEMKPHS-9.1e-12--6.4e-85.8e-5--8.4e-8-2.3e-8-0.056--7.3e-4-0.67
S365EKPRKQLSSQGTVRF-0.049--------0.088-7.1e-6
S366KPRKQLSSQGTVRFF-----------
Showing 1 to 10 of 10 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PATH-NP_EGFR1_PATHWAYS1392.4e-90.940.0470.163.4e-36.6e-30.090.078-1.6e-50.31
KINASE-PSP_PKCA/PRKCAS1153.6e-80.038-4.9e-32.9e-30.981.5e-30.0680.0220.730.31
HALLMARK_APICAL_JUNCTIONS1394.7e-80.190.020.40.0950.062.2e-30.008-0.70.20.009
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONS1395.5e-80.140.0280.980.040.0546.9e-40.048-0.480.139.8e-4
HALLMARK_HYPOXIAS1397.8e-80.540.013-0.949.1e-42.6e-38.8e-30.0160.30.740.21
HALLMARK_UV_RESPONSE_DNS1396.2e-70.460.0890.140.0260.0414.6e-30.12-0.430.26.2e-3
HALLMARK_COAGULATIONS1398.1e-70.139.6e-3-0.90.0626.4e-50.0020.056-0.32-0.129.2e-4
KINASE-PSP_PKACA/PRKACAS3651.1e-6---0.0420.38---0.573.1e-51.2e-5
ESTIMATE: StromalScoreS1391.1e-60.190.13-0.440.547.7e-43.2e-40.038-0.530.22.6e-3
HALLMARK_MYOGENESISS1391.3e-60.0310.290.620.0960.110.120.13-0.760.0251.1e-3
Showing 1 to 10 of 2580 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS25T49S96S115S128S132S134S139S365S366proteinRNASCNVmethylationCCRCCS25T49S96S115S128S132S134S139S365S366proteinRNASCNVmethylationCOADS25T49S96S115S128S132S134S139S365S366proteinRNASCNVmethylationGBMS25T49S96S115S128S132S134S139S365S366proteinRNASCNVmethylationHNSCCS25T49S96S115S128S132S134S139S365S366proteinRNASCNVmethylationLSCCS25T49S96S115S128S132S134S139S365S366proteinRNASCNVmethylationLUADS25T49S96S115S128S132S134S139S365S366proteinRNASCNVmethylationOVS25T49S96S115S128S132S134S139S365S366proteinRNASCNVmethylationPDACS25T49S96S115S128S132S134S139S365S366proteinRNASCNVmethylationUCECS25T49S96S115S128S132S134S139S365S366proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.