STK10: serine/threonine kinase 10
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2j7t chain A
4aot chain A
4aot chain B
4bc6 chain A
4equ chain A
4equ chain B
4usd chain A
4usd chain B
4use chain A
4use chain B
5ajq chain A
5ajq chain B
5owq chain A
5owq chain B
5owr chain A
6eim chain A
6eim chain B
6gtt chain A
6hxf chain A
6hxf chain B
6hxf chain C
6hxf chain D
6i2y chain A
6i2y chain B
7qgp chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
Loading, please wait
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S13 FRRILRLS TFEKRKS 10 833 30 - 18 16 87 84 99 - 73 45 10 8 44 41 48 11 105 44 54 16 T14 RRILRLST FEKRKSR 9 788 81 - 63 52 64 70 80 - - - 78 72 44 41 14 4 65 29 22 9 S20 STFEKRKS REYEHVR 10 1126 98 - 50 37 97 100 81 - 102 59 78 74 44 40 55 13 90 37 55 16 T185 VSAKNLKT LQKRDSF 2 88 79 - - - - - - - - - 5 4 - - - - - - - - S191 KTLQKRDS FIGTPYW 10 1374 122 - 103 80 84 78 99 - 108 62 108 99 110 101 14 3 105 44 38 16 Y197 DSFIGTPY WMAPEVV 2 16 - - - - - - - - - - - - 4 4 6 2 - - - - T208 PEVVMCET MKDTPYD 2 14 - - - - - - - - - - - - - - 8 - - - 6 - S371 TPLAPSQS QDSVNEP 6 130 - - 8 - - - - - 12 7 10 9 5 4 - - 48 21 6 - S374 APSQSQDS VNEPCSQ 6 201 - - 48 31 - - - - 12 7 10 9 5 4 - - 48 21 6 - T391 GDRSLQTT SPPVVAP 1 6 - - - - - - - - - - - - - - - - 5 1 - -
Tumor and normal comparison
Loading, please wait
Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S13 FRRILRLS TFEKRKS -0.87 - - -0.17 - 1.3e-4 - -2.1e-4 3.6e-3 0.024 -1.6e-5 T14 RRILRLST FEKRKSR -3.6e-7 - 5.0e-5 -1.2e-8 - - -6.3e-20 -2.1e-4 - 1.9e-3 - S20 STFEKRKS REYEHVR -2.2e-11 - 2.4e-5 -0.074 - -1.5e-8 -2e-21 -8e-10 0.64 5.9e-4 -8.1e-5 T185 VSAKNLKT LQKRDSF - - - - - - - - - - - S191 KTLQKRDS FIGTPYW -5.9e-8 - 1.7e-13 -1.3e-3 - -8.1e-11 -1.1e-13 -1.2e-9 - 3.0e-4 -0.035 Y197 DSFIGTPY WMAPEVV - - - - - - - - - - - T208 PEVVMCET MKDTPYD - - - - - - - - - - - S371 TPLAPSQS QDSVNEP -0.67 - - - - - - - - -0.67 - S374 APSQSQDS VNEPCSQ 5.8e-3 - 1.5e-5 - - - - - - -0.67 - T391 GDRSLQTT SPPVVAP - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
Loading, please wait
all sites
S13
T14
S20
T185
S191
Y197
T208
S371
S374
T391
S392
S417
S438
S444
S448
S450
S454
S455
S469
S485
S488
S493
S495
Y498
T500
S503
T504
S514
S516
S824
S951
T952
S964
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S13 T14 S20 T185 S191 Y197 T208 S371 S374 T391 S392 S417 S438 S444 S448 S450 S454 S455 S469 S485 S488 S493 S495 Y498 T500 S503 T504 S514 S516 S824 S951 T952 S964 protein RNA SCNV methylation CCRCC S13 T14 S20 T185 S191 Y197 T208 S371 S374 T391 S392 S417 S438 S444 S448 S450 S454 S455 S469 S485 S488 S493 S495 Y498 T500 S503 T504 S514 S516 S824 S951 T952 S964 protein RNA SCNV methylation COAD S13 T14 S20 T185 S191 Y197 T208 S371 S374 T391 S392 S417 S438 S444 S448 S450 S454 S455 S469 S485 S488 S493 S495 Y498 T500 S503 T504 S514 S516 S824 S951 T952 S964 protein RNA SCNV methylation GBM S13 T14 S20 T185 S191 Y197 T208 S371 S374 T391 S392 S417 S438 S444 S448 S450 S454 S455 S469 S485 S488 S493 S495 Y498 T500 S503 T504 S514 S516 S824 S951 T952 S964 protein RNA SCNV methylation HNSCC S13 T14 S20 T185 S191 Y197 T208 S371 S374 T391 S392 S417 S438 S444 S448 S450 S454 S455 S469 S485 S488 S493 S495 Y498 T500 S503 T504 S514 S516 S824 S951 T952 S964 protein RNA SCNV methylation LSCC S13 T14 S20 T185 S191 Y197 T208 S371 S374 T391 S392 S417 S438 S444 S448 S450 S454 S455 S469 S485 S488 S493 S495 Y498 T500 S503 T504 S514 S516 S824 S951 T952 S964 protein RNA SCNV methylation LUAD S13 T14 S20 T185 S191 Y197 T208 S371 S374 T391 S392 S417 S438 S444 S448 S450 S454 S455 S469 S485 S488 S493 S495 Y498 T500 S503 T504 S514 S516 S824 S951 T952 S964 protein RNA SCNV methylation OV S13 T14 S20 T185 S191 Y197 T208 S371 S374 T391 S392 S417 S438 S444 S448 S450 S454 S455 S469 S485 S488 S493 S495 Y498 T500 S503 T504 S514 S516 S824 S951 T952 S964 protein RNA SCNV methylation PDAC S13 T14 S20 T185 S191 Y197 T208 S371 S374 T391 S392 S417 S438 S444 S448 S450 S454 S455 S469 S485 S488 S493 S495 Y498 T500 S503 T504 S514 S516 S824 S951 T952 S964 protein RNA SCNV methylation UCEC S13 T14 S20 T185 S191 Y197 T208 S371 S374 T391 S392 S417 S438 S444 S448 S450 S454 S455 S469 S485 S488 S493 S495 Y498 T500 S503 T504 S514 S516 S824 S951 T952 S964 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S13
T14
S20
T185
S191
Y197
T208
S371
S374
T391
S392
S417
S438
S444
S448
S450
S454
S455
S469
S485
S488
S493
S495
Y498
T500
S503
T504
S514
S516
S824
S951
T952
S964
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S13
T14
S20
T185
S191
Y197
T208
S371
S374
T391
S392
S417
S438
S444
S448
S450
S454
S455
S469
S485
S488
S493
S495
Y498
T500
S503
T504
S514
S516
S824
S951
T952
S964
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.