Protein: ENSP00000193403
Gene: ACTN1

LinkedOmicsKB © 2022-2023 Zhang Lab

ACTN1:
actinin alpha 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T50SHLRKAGTQIENIEE6293------63-9640382624--4216254
S91KMRVHKISNVNKALD6694--7354----33181039510597--783152
S172NIQNFHISWKDGLGF71037--9976--90-10159108999790--105445316
Y193HRPELIDYGKLRKDD6414--3923--27-5328696387--6928--
T230DAEDIVGTARPDEKA7505--6344--9-241373683332--5725577
S348LQTKLRLSNRPAFMP7976--9572--44-102599889110101--105444116
S356NRPAFMPSEGRMVSD4309--2423------58546760--167--
S362PSEGRMVSDINNAWG6876--9580----1025994869688--95383112
S428DYETATLSEIKALLK6212--44--10---38353433--32454
S471LDYYDSPSVNARCQK18--44----------------
Showing 1 to 10 of 17 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T50SHLRKAGTQIENIEE-1.8e-7------6.6e-7-3e-10-0.025-
S91KMRVHKISNVNKALD-1.1e-6--0.012--0.24-4.9e-17-9.4e-17-9.1e-13-
S172NIQNFHISWKDGLGF-2.8e-4--0.12--3.5e-7-7e-12-2.8e-7-0.017-0.005
Y193HRPELIDYGKLRKDD-0.01--3.9e-4--0.490.89---0.016-
T230DAEDIVGTARPDEKA-0.026--0.12---0.44-0.019-0.58-0.82-
S348LQTKLRLSNRPAFMP3e-19--0.046--6.8e-211.2e-3-0.88-1.7e-172.8e-3
S356NRPAFMPSEGRMVSD-1.7e-3--0.025----0.022-0.36---
S362PSEGRMVSDINNAWG2.9e-5--5.3e-8--1.9e-14-0.060.25-4.7e-120.067
S428DYETATLSEIKALLK-1.7e-20------2.9e-13-5.8e-9---
S471LDYYDSPSVNARCQK-----------
Showing 1 to 10 of 17 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAT50S91S172Y193T230S348S356S362S428S471S576S677S797T823T825Y887S890proteinRNASCNVmethylationCCRCCT50S91S172Y193T230S348S356S362S428S471S576S677S797T823T825Y887S890proteinRNASCNVmethylationCOADT50S91S172Y193T230S348S356S362S428S471S576S677S797T823T825Y887S890proteinRNASCNVmethylationGBMT50S91S172Y193T230S348S356S362S428S471S576S677S797T823T825Y887S890proteinRNASCNVmethylationHNSCCT50S91S172Y193T230S348S356S362S428S471S576S677S797T823T825Y887S890proteinRNASCNVmethylationLSCCT50S91S172Y193T230S348S356S362S428S471S576S677S797T823T825Y887S890proteinRNASCNVmethylationLUADT50S91S172Y193T230S348S356S362S428S471S576S677S797T823T825Y887S890proteinRNASCNVmethylationOVT50S91S172Y193T230S348S356S362S428S471S576S677S797T823T825Y887S890proteinRNASCNVmethylationPDACT50S91S172Y193T230S348S356S362S428S471S576S677S797T823T825Y887S890proteinRNASCNVmethylationUCECT50S91S172Y193T230S348S356S362S428S471S576S677S797T823T825Y887S890proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.