MISP: mitotic spindle positioning
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S78 HAYTGQPS PRGLHSE 7 348 9 - - - 84 77 - - 21 8 - - 19 16 41 10 19 8 30 6 S84 PSPRGLHS ENREDEG 3 158 - - - - 65 60 - - - - - - 5 4 - - 18 6 - - S155 QGQAVRKS STVATLQ 1 9 - - - - 4 5 - - - - - - - - - - - - - - S156 GQAVRKSS TVATLQG 9 756 8 - 4 4 63 54 - - 70 40 75 68 46 41 57 12 78 32 95 9 T157 QAVRKSST VATLQGT 3 27 - - - - 5 4 - - - - - - - - - - 5 1 12 - T160 RKSSTVAT LQGTPDH 3 24 - - - - 4 5 - - - - - - - - - - 5 2 5 3 T164 TVATLQGT PDHGDPR 5 96 - - - - 17 27 - - - - 5 4 5 4 21 5 - - 5 3 T172 PDHGDPRT PGPPRST 3 168 - - - - 20 24 - - - - - - - - - - 48 20 54 2 S178 RTPGPPRS TPLEENV 1 9 - - - - 3 6 - - - - - - - - - - - - - - T179 TPGPPRST PLEENVV 5 131 23 - - - 27 27 - - - - - - 14 12 - - 9 3 16 -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S78 HAYTGQPS PRGLHSE 0.083 - - 0.015 - - - - 0.99 - - S84 PSPRGLHS ENREDEG -3.7e-4 - - -3.7e-4 - - - - - - - S155 QGQAVRKS STVATLQ - - - - - - - - - - - S156 GQAVRKSS TVATLQG -0.95 - - -4.1e-3 - 1.4e-3 -2.8e-5 -0.39 0.059 7.3e-3 - T157 QAVRKSST VATLQGT - - - - - - - - - - - T160 RKSSTVAT LQGTPDH - - - - - - - - - - - T164 TVATLQGT PDHGDPR - - - - - - - - - - - T172 PDHGDPRT PGPPRST -0.019 - - -8.1e-5 - - - - - 0.53 - S178 RTPGPPRS TPLEENV - - - - - - - - - - - T179 TPGPPRST PLEENVV -0.68 - - -0.68 - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S78
S84
S155
S156
T157
T160
T164
T172
S178
T179
S202
S214
T219
T224
S269
S278
S281
S284
T287
T327
S335
S348
S376
T377
S394
S395
S397
S400
S430
T433
S449
S471
S473
S474
S485
S541
S543
S544
S553
S575
T577
S582
S586
S675
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S78 S84 S155 S156 T157 T160 T164 T172 S178 T179 S202 S214 T219 T224 S269 S278 S281 S284 T287 T327 S335 S348 S376 T377 S394 S395 S397 S400 S430 T433 S449 S471 S473 S474 S485 S541 S543 S544 S553 S575 T577 S582 S586 S675 protein RNA SCNV methylation CCRCC S78 S84 S155 S156 T157 T160 T164 T172 S178 T179 S202 S214 T219 T224 S269 S278 S281 S284 T287 T327 S335 S348 S376 T377 S394 S395 S397 S400 S430 T433 S449 S471 S473 S474 S485 S541 S543 S544 S553 S575 T577 S582 S586 S675 protein RNA SCNV methylation COAD S78 S84 S155 S156 T157 T160 T164 T172 S178 T179 S202 S214 T219 T224 S269 S278 S281 S284 T287 T327 S335 S348 S376 T377 S394 S395 S397 S400 S430 T433 S449 S471 S473 S474 S485 S541 S543 S544 S553 S575 T577 S582 S586 S675 protein RNA SCNV methylation GBM S78 S84 S155 S156 T157 T160 T164 T172 S178 T179 S202 S214 T219 T224 S269 S278 S281 S284 T287 T327 S335 S348 S376 T377 S394 S395 S397 S400 S430 T433 S449 S471 S473 S474 S485 S541 S543 S544 S553 S575 T577 S582 S586 S675 protein RNA SCNV methylation HNSCC S78 S84 S155 S156 T157 T160 T164 T172 S178 T179 S202 S214 T219 T224 S269 S278 S281 S284 T287 T327 S335 S348 S376 T377 S394 S395 S397 S400 S430 T433 S449 S471 S473 S474 S485 S541 S543 S544 S553 S575 T577 S582 S586 S675 protein RNA SCNV methylation LSCC S78 S84 S155 S156 T157 T160 T164 T172 S178 T179 S202 S214 T219 T224 S269 S278 S281 S284 T287 T327 S335 S348 S376 T377 S394 S395 S397 S400 S430 T433 S449 S471 S473 S474 S485 S541 S543 S544 S553 S575 T577 S582 S586 S675 protein RNA SCNV methylation LUAD S78 S84 S155 S156 T157 T160 T164 T172 S178 T179 S202 S214 T219 T224 S269 S278 S281 S284 T287 T327 S335 S348 S376 T377 S394 S395 S397 S400 S430 T433 S449 S471 S473 S474 S485 S541 S543 S544 S553 S575 T577 S582 S586 S675 protein RNA SCNV methylation OV S78 S84 S155 S156 T157 T160 T164 T172 S178 T179 S202 S214 T219 T224 S269 S278 S281 S284 T287 T327 S335 S348 S376 T377 S394 S395 S397 S400 S430 T433 S449 S471 S473 S474 S485 S541 S543 S544 S553 S575 T577 S582 S586 S675 protein RNA SCNV methylation PDAC S78 S84 S155 S156 T157 T160 T164 T172 S178 T179 S202 S214 T219 T224 S269 S278 S281 S284 T287 T327 S335 S348 S376 T377 S394 S395 S397 S400 S430 T433 S449 S471 S473 S474 S485 S541 S543 S544 S553 S575 T577 S582 S586 S675 protein RNA SCNV methylation UCEC S78 S84 S155 S156 T157 T160 T164 T172 S178 T179 S202 S214 T219 T224 S269 S278 S281 S284 T287 T327 S335 S348 S376 T377 S394 S395 S397 S400 S430 T433 S449 S471 S473 S474 S485 S541 S543 S544 S553 S575 T577 S582 S586 S675 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S78
S84
S155
S156
T157
T160
T164
T172
S178
T179
S202
S214
T219
T224
S269
S278
S281
S284
T287
T327
S335
S348
S376
T377
S394
S395
S397
S400
S430
T433
S449
S471
S473
S474
S485
S541
S543
S544
S553
S575
T577
S582
S586
S675
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S78
S84
S155
S156
T157
T160
T164
T172
S178
T179
S202
S214
T219
T224
S269
S278
S281
S284
T287
T327
S335
S348
S376
T377
S394
S395
S397
S400
S430
T433
S449
S471
S473
S474
S485
S541
S543
S544
S553
S575
T577
S582
S586
S675
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.