MAPK1: mitogen-activated protein kinase 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1pme chain A
1tvo chain A
1wzy chain A
2ojg chain A
2oji chain A
2ojj chain A
2y9q chain A
3d42 chain B
3d44 chain B
3i5z chain A
3i60 chain A
3sa0 chain A
3tei chain A
3w55 chain A
4fmq chain A
4fux chain A
4fuy chain A
4fv0 chain A
4fv1 chain A
4fv2 chain A
4fv3 chain A
4fv4 chain A
4fv5 chain A
4fv6 chain A
4fv7 chain A
4fv8 chain A
4fv9 chain A
4g6n chain A
4g6o chain A
4h3p chain A
4h3p chain D
4h3q chain A
4iz5 chain A
4iz5 chain B
4iz5 chain C
4iz5 chain D
4iz7 chain A
4iz7 chain C
4iza chain A
4iza chain C
4n0s chain A
4nif chain B
4nif chain E
4o6e chain A
4qp1 chain A
4qp1 chain B
4qp2 chain A
4qp2 chain B
4qp3 chain A
4qp3 chain B
4qp4 chain A
4qp4 chain B
4qp6 chain A
4qp6 chain B
4qp7 chain A
4qp7 chain B
4qp8 chain A
4qp8 chain B
4qp9 chain A
4qpa chain A
4qpa chain B
4qta chain A
4qte chain A
4xj0 chain A
4xj0 chain B
4zxt chain A
4zzm chain A
4zzn chain A
4zzo chain A
5ax3 chain A
5bue chain A
5bui chain A
5buj chain A
5bvd chain A
5bve chain A
5bvf chain A
5k4i chain A
5lcj chain A
5lck chain A
5ngu chain A
5nhf chain A
5nhh chain A
5nhj chain A
5nhl chain A
5nho chain A
5nhp chain A
5nhv chain A
5v60 chain A
5v61 chain A
5v62 chain A
5wp1 chain A
6d5y chain A
6dmg chain A
6g54 chain A
6g8x chain A
6g91 chain A
6g92 chain A
6g93 chain A
6g97 chain A
6g9a chain A
6g9d chain A
6g9h chain A
6g9j chain A
6g9k chain A
6g9m chain A
6g9n chain A
6gdm chain A
6gdq chain A
6ge0 chain A
6gjb chain A
6gjd chain A
6nbs chain A
6opg chain A
6oph chain A
6opi chain A
6q7k chain A
6q7s chain A
6q7t chain A
6qa1 chain A
6qa3 chain A
6qa4 chain A
6qag chain A
6qah chain A
6qal chain A
6qaq chain A
6qaw chain A
6rq4 chain A
6slg chain A
7auv chain A
7e73 chain A
7e75 chain A
7nqq chain A
7nqw chain A
7nr3 chain A
7nr5 chain A
7nr8 chain A
7nr9 chain A
7opm chain A
7w5o chain A
7w5o chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
Loading, please wait
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
Y30 PRYTNLSY IGEGAYG 2 20 - - - - - - - - 6 4 5 5 - - - - - - - - Y36 SYIGEGAY GMVCSAY 1 9 - - - - - - 9 - - - - - - - - - - - - - T181 ADPDHDHT GFLTEYV 4 43 8 - 9 8 - - 9 - - - 4 5 - - - - - - - - T185 HDHTGFLT EYVATRW 10 677 17 - 5 4 74 78 81 - 80 46 24 21 85 77 39 10 5 3 26 2 Y187 HTGFLTEY VATRWYR 10 1520 105 - 95 72 97 100 99 - 108 62 108 99 110 101 83 19 105 44 95 18 S248 LGILGSPS QEDLNCI 1 17 - - - - - - 17 - - - - - - - - - - - - - S284 RLFPNADS KALDLLD 1 36 - - - - - - 36 - - - - - - - - - - - - - S320 LEQYYDPS DEPIAEA 1 28 - - - - - - 28 - - - - - - - - - - - - - S360 RFQPGYRS _______ 10 848 26 - 103 80 17 18 99 - 97 57 14 12 73 64 25 8 86 37 32 -
Tumor and normal comparison
Loading, please wait
Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Y30 PRYTNLSY IGEGAYG - - - - - - - - - - - Y36 SYIGEGAY GMVCSAY - - - - - - - - - - - T181 ADPDHDHT GFLTEYV - - - - - - - - - - - T185 HDHTGFLT EYVATRW -4.1e-34 - - -0.027 - -4.3e-15 -1.0e-4 -4e-23 -7.4e-4 - - Y187 HTGFLTEY VATRWYR -6.3e-12 - 2.9e-17 -3.1e-12 - -9.3e-8 -1.2e-19 -8.8e-24 0.11 3.5e-6 -0.015 S248 LGILGSPS QEDLNCI - - - - - - - - - - - S284 RLFPNADS KALDLLD - - - - - - - - - - - S320 LEQYYDPS DEPIAEA - - - - - - - - - - - S360 RFQPGYRS _______ -0.14 - 3.7e-17 - - 3.8e-3 - -4.9e-18 - -6.6e-8 -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
Loading, please wait
all sites
Y30
Y36
T181
T185
Y187
S248
S284
S320
S360
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA Y30 Y36 T181 T185 Y187 S248 S284 S320 S360 protein RNA SCNV methylation CCRCC Y30 Y36 T181 T185 Y187 S248 S284 S320 S360 protein RNA SCNV methylation COAD Y30 Y36 T181 T185 Y187 S248 S284 S320 S360 protein RNA SCNV methylation GBM Y30 Y36 T181 T185 Y187 S248 S284 S320 S360 protein RNA SCNV methylation HNSCC Y30 Y36 T181 T185 Y187 S248 S284 S320 S360 protein RNA SCNV methylation LSCC Y30 Y36 T181 T185 Y187 S248 S284 S320 S360 protein RNA SCNV methylation LUAD Y30 Y36 T181 T185 Y187 S248 S284 S320 S360 protein RNA SCNV methylation OV Y30 Y36 T181 T185 Y187 S248 S284 S320 S360 protein RNA SCNV methylation PDAC Y30 Y36 T181 T185 Y187 S248 S284 S320 S360 protein RNA SCNV methylation UCEC Y30 Y36 T181 T185 Y187 S248 S284 S320 S360 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
Y30
Y36
T181
T185
Y187
S248
S284
S320
S360
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
Y30
Y36
T181
T185
Y187
S248
S284
S320
S360
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.