Protein: ENSP00000216122
Gene: MCM5

LinkedOmicsKB © 2022-2023 Zhang Lab

MCM5:
minichromosome maintenance complex component 5

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S315RSFAGAVSPQEEEEF81438-44--17-21141414--124521311
T347APSIFGGTDMKKAIA16----------------51--
T509DNIDFMPTILSRFDM18--------------71----
S605RDSDRRSSIPITVRQ359--88----2411----71----
Showing 1 to 4 of 4 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S315RSFAGAVSPQEEEEF2.0e-4----2.0e-4-----
T347APSIFGGTDMKKAIA-----------
T509DNIDFMPTILSRFDM-----------
S605RDSDRRSSIPITVRQ0.9----0.9-----
Showing 1 to 4 of 4 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_E2F_TARGETSS3158.8e-6---4.7e-40.327.1e-4-0.13-0.59
HALLMARK_G2M_CHECKPOINTS3151.8e-5---4.2e-30.150.006-0.25-0.17
HALLMARK_DNA_REPAIRS3158.1e-5---0.180.20.015-1.7e-3-0.54
Tumor Purity (WGS)S3151.7e-4---0.0340.114.4e-4---0.8
xcell: T cell CD4+ Th1S3153.0e-4---0.270.0780.012-0.094-0.3
chromosomal instabilityS3153.7e-4---0.520.593.3e-4-0.17-0.071
HALLMARK_MYC_TARGETS_V2S3156.1e-4---0.180.160.084-0.035-0.27
Tumor Purity (ABSOLUTE)S3151.1e-3---0.0210.671.4e-3-0.35-0.67
KINASE-PSP_CK2A1/CSNK2A1S3151.3e-3---3.4e-30.50.032-0.62-0.35
KINASE-PSP_GSK3BS3154.9e-3---0.260.0490.48---0.067
Showing 1 to 10 of 1032 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS315T347T509S605proteinRNASCNVmethylationCCRCCS315T347T509S605proteinRNASCNVmethylationCOADS315T347T509S605proteinRNASCNVmethylationGBMS315T347T509S605proteinRNASCNVmethylationHNSCCS315T347T509S605proteinRNASCNVmethylationLSCCS315T347T509S605proteinRNASCNVmethylationLUADS315T347T509S605proteinRNASCNVmethylationOVS315T347T509S605proteinRNASCNVmethylationPDACS315T347T509S605proteinRNASCNVmethylationUCECS315T347T509S605proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.