HSP90AA1:
heat shock protein 90 alpha family class A member 1

Lollipop plot

Phosphosites location and occurrence

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Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S52LRELISNSSDALDKI5201------71-33201514----73317
S211KEIVKKHSQFIGYPI118------18-------------
S231KERDKEVSDDEAEEK101553122-103809710099-10862108991101018319105449518
S252KEKEEKESEDKPEIE877822-8057--98-1015949455552--9540205
S263PEIEDVGSDEEEEKK101553122-103809710099-10862108991101018319105449518
S453KLGIHEDSQNRKKLS101463122-10380737990-9756108991101017518105448518
S476ASGDEMVSLKDYCTR101352122-8865333999-1086210899110101781578349518
Y492KENQKHIYYITGETK16------------------6-
S595VSNRLVTSPCCIVTS10932106-2020423853-96568879948426540175018
T601TSPCCIVTSTYGWTA19------------54------
Showing 1 to 10 of 20 rows
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Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S52LRELISNSSDALDKI0.43----0.43-----
S211KEIVKKHSQFIGYPI-----------
S231KERDKEVSDDEAEEK5.1e-19--7.5e-240.02-3.2e-162.7e-244.5e-212.9e-3-9.7e-33.3e-3
S252KEKEEKESEDKPEIE0.36--2.8e-4--7.8e-8-0.551.1e-6--7.2e-5-
S263PEIEDVGSDEEEEKK8.4e-14--4.6e-270.64-6.4e-73.8e-182.8e-229.2e-6-6.6e-54.6e-7
S453KLGIHEDSQNRKKLS8.4e-9--4.2e-247.6e-5-0.0661.3e-231e-110.21-0.0468.6e-3
S476ASGDEMVSLKDYCTR2.7e-21--4.3e-191.5e-6-7.8e-176.5e-128.6e-147.6e-30.232.7e-4
Y492KENQKHIYYITGETK-----------
S595VSNRLVTSPCCIVTS-0.072-0.88-1e-7--5.8e-60.072-0.32-0.944.8e-5
T601TSPCCIVTSTYGWTA-----------
Showing 1 to 10 of 20 rows
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS52S211S231S252S263S453S476Y492S595T601S602S623T624S641T704T708S709T713T725S726proteinRNASCNVmethylationCCRCCS52S211S231S252S263S453S476Y492S595T601S602S623T624S641T704T708S709T713T725S726proteinRNASCNVmethylationCOADS52S211S231S252S263S453S476Y492S595T601S602S623T624S641T704T708S709T713T725S726proteinRNASCNVmethylationGBMS52S211S231S252S263S453S476Y492S595T601S602S623T624S641T704T708S709T713T725S726proteinRNASCNVmethylationHNSCCS52S211S231S252S263S453S476Y492S595T601S602S623T624S641T704T708S709T713T725S726proteinRNASCNVmethylationLSCCS52S211S231S252S263S453S476Y492S595T601S602S623T624S641T704T708S709T713T725S726proteinRNASCNVmethylationLUADS52S211S231S252S263S453S476Y492S595T601S602S623T624S641T704T708S709T713T725S726proteinRNASCNVmethylationOVS52S211S231S252S263S453S476Y492S595T601S602S623T624S641T704T708S709T713T725S726proteinRNASCNVmethylationPDACS52S211S231S252S263S453S476Y492S595T601S602S623T624S641T704T708S709T713T725S726proteinRNASCNVmethylationUCECS52S211S231S252S263S453S476Y492S595T601S602S623T624S641T704T708S709T713T725S726proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.