VRK1: VRK serine/threonine kinase 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2kty chain A
2kul chain A
2lav chain A
2rsv chain A
3op5 chain A
3op5 chain B
3op5 chain C
3op5 chain D
5ukf chain A
5ukf chain B
5ukf chain C
5ukf chain D
5uvf chain A
5uvf chain B
5uvf chain C
5uvf chain D
6ac9 chain A
6ac9 chain B
6ac9 chain C
6ac9 chain D
6bp0 chain A
6bp0 chain B
6bp0 chain C
6bp0 chain D
6bru chain A
6bru chain B
6bru chain C
6bru chain D
6btw chain A
6btw chain B
6btw chain C
6btw chain D
6bu6 chain A
6bu6 chain B
6bu6 chain C
6bu6 chain D
6cfm chain A
6cfm chain B
6cfm chain C
6cfm chain D
6cmm chain A
6cmm chain B
6cmm chain C
6cmm chain D
6cnx chain A
6cnx chain B
6cnx chain C
6cnx chain D
6cqh chain A
6cqh chain B
6cqh chain C
6cqh chain D
6csw chain A
6csw chain B
6csw chain C
6csw chain D
6dd4 chain A
6dd4 chain B
6dd4 chain C
6dd4 chain D
6npn chain A
6npn chain B
6npn chain C
6npn chain D
6vxu chain A
6vxu chain B
6vxu chain C
6vxu chain D
6vzh chain A
6vzh chain B
6vzh chain C
6vzh chain D
7m10 chain B
7tan chain K
7tan chain L
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S13 AAQAGRQS SAKRHLA 1 8 - - - - - - - - - - - - 4 4 - - - - - - S342 DDGKLDLS VVENGGL 1 9 - - - - - - - - - - 5 4 - - - - - - - - S365 RKKEIEES KEPGVED 1 18 - - - - - - - - - - - - - - - - - - 18 - T373 KEPGVEDT EWSNTQT 1 10 - - - - - - - - - - 5 5 - - - - - - - - S376 GVEDTEWS NTQTEEA 10 1275 97 - 82 69 66 68 62 - 108 62 108 98 105 97 53 12 53 22 95 18 T378 EDTEWSNT QTEEAIQ 1 9 - - - - - - - - - - - - - - - - - - - 9
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S13 AAQAGRQS SAKRHLA - - - - - - - - - - - S342 DDGKLDLS VVENGGL - - - - - - - - - - - S365 RKKEIEES KEPGVED - - - - - - - - - - - T373 KEPGVEDT EWSNTQT - - - - - - - - - - - S376 GVEDTEWS NTQTEEA 7.4e-35 - 0.39 3.5e-7 - 8.5e-17 6.2e-21 2.4e-7 0.37 0.37 2.6e-5 T378 EDTEWSNT QTEEAIQ - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S13
S342
S365
T373
S376
T378
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S13 S342 S365 T373 S376 protein RNA SCNV methylation CCRCC S13 S342 S365 T373 S376 protein RNA SCNV methylation COAD S13 S342 S365 T373 S376 protein RNA SCNV methylation GBM S13 S342 S365 T373 S376 protein RNA SCNV methylation HNSCC S13 S342 S365 T373 S376 protein RNA SCNV methylation LSCC S13 S342 S365 T373 S376 protein RNA SCNV methylation LUAD S13 S342 S365 T373 S376 protein RNA SCNV methylation OV S13 S342 S365 T373 S376 protein RNA SCNV methylation PDAC S13 S342 S365 T373 S376 protein RNA SCNV methylation UCEC S13 S342 S365 T373 S376 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S13
S342
S365
T373
S376
T378
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S13
S342
S365
T373
S376
T378
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.