APEX1: apurinic/apyrimidinic endodeoxyribonuclease 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1bix chain A
1cqg chain B
1cqh chain B
1de8 chain A
1de8 chain B
1de9 chain A
1de9 chain B
1dew chain A
1dew chain B
1e9n chain A
1e9n chain B
1hd7 chain A
2isi chain A
2isi chain B
2isi chain C
2o3h chain A
3u8u chain A
3u8u chain B
3u8u chain C
3u8u chain D
3u8u chain E
3u8u chain F
4iem chain A
4iem chain B
4iem chain C
4iem chain D
4lnd chain A
4lnd chain B
4lnd chain C
4qh9 chain A
4qhd chain A
4qhe chain A
5cfg chain A
5dff chain A
5dff chain B
5dfh chain A
5dfh chain B
5dfi chain A
5dfi chain B
5dfj chain A
5dfj chain B
5dg0 chain A
5dg0 chain B
5wn0 chain A
5wn0 chain B
5wn1 chain A
5wn1 chain B
5wn2 chain A
5wn2 chain B
5wn3 chain A
5wn3 chain B
5wn4 chain A
5wn4 chain B
5wn5 chain A
5wn5 chain B
6boq chain A
6boq chain B
6bor chain A
6bor chain B
6bos chain A
6bos chain B
6bot chain A
6bot chain B
6bou chain A
6bou chain B
6bov chain A
6bov chain B
6bow chain A
6bow chain B
6mk3 chain A
6mkk chain A
6mkm chain A
6mko chain A
6p93 chain A
6p93 chain B
6p94 chain A
6p94 chain B
6w0q chain A
6w0q chain B
6w2p chain A
6w2p chain B
6w3l chain A
6w3l chain B
6w3n chain A
6w3n chain B
6w3q chain A
6w3q chain B
6w3u chain A
6w3u chain B
6w43 chain A
6w43 chain B
6w4i chain A
6w4i chain B
6w4t chain A
6w4t chain B
7lpg chain B
7lpg chain D
7lph chain B
7lph chain D
7lpi chain B
7lpi chain D
7lpj chain B
7lpj chain D
7mcr chain A
7mev chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T19 EDGDELRT EPEAKKS 6 115 8 - 22 12 6 3 - - - - - - - - 38 7 5 1 13 - S54 DPPDQKTS PSGKPAT 6 153 - - - - - - 9 - - - 20 19 10 8 7 1 25 10 28 16 S56 PDQKTSPS GKPATLK 1 8 - - - - - - - - - - - - - - - - - - 8 - S115 LQELPGLS HQYWSAP 1 10 - - - - - - - - 6 4 - - - - - - - - - - Y118 LPGLSHQY WSAPSDK 2 37 7 - - - - - - - - - 15 15 - - - - - - - - S120 GLSHQYWS APSDKEG 3 59 15 - - - - - - - 21 14 5 4 - - - - - - - - S123 HQYWSAPS DKEGYSG 2 26 - - - - - - - - 6 3 - - - - - - - - 13 4 S252 QAVPLADS FRHLYPN 2 18 - - - - - - 10 - - - - - 4 4 - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T19 EDGDELRT EPEAKKS -0.66 - -0.66 - - - - - - - - S54 DPPDQKTS PSGKPAT 9.3e-4 - - - - - 2.3e-4 - - 0.4 0.23 S56 PDQKTSPS GKPATLK - - - - - - - - - - - S115 LQELPGLS HQYWSAP - - - - - - - - - - - Y118 LPGLSHQY WSAPSDK - - - - - - - - - - - S120 GLSHQYWS APSDKEG 0.19 - - - - 0.19 - - - - - S123 HQYWSAPS DKEGYSG - - - - - - - - - - - S252 QAVPLADS FRHLYPN - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
T19
S54
S56
S115
Y118
S120
S123
S252
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA T19 S54 S56 S115 Y118 S120 S123 S252 protein RNA SCNV methylation CCRCC T19 S54 S56 S115 Y118 S120 S123 S252 protein RNA SCNV methylation COAD T19 S54 S56 S115 Y118 S120 S123 S252 protein RNA SCNV methylation GBM T19 S54 S56 S115 Y118 S120 S123 S252 protein RNA SCNV methylation HNSCC T19 S54 S56 S115 Y118 S120 S123 S252 protein RNA SCNV methylation LSCC T19 S54 S56 S115 Y118 S120 S123 S252 protein RNA SCNV methylation LUAD T19 S54 S56 S115 Y118 S120 S123 S252 protein RNA SCNV methylation OV T19 S54 S56 S115 Y118 S120 S123 S252 protein RNA SCNV methylation PDAC T19 S54 S56 S115 Y118 S120 S123 S252 protein RNA SCNV methylation UCEC T19 S54 S56 S115 Y118 S120 S123 S252 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
T19
S54
S56
S115
Y118
S120
S123
S252
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
T19
S54
S56
S115
Y118
S120
S123
S252
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.