Protein: ENSP00000218348
Gene: USP11

LinkedOmicsKB © 2022-2023 Zhang Lab

USP11:
ubiquitin specific peptidase 11

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S536LSKHTGISPERMMVA19--------------72----
S648RYVTKPNSDDEDDGD91258112-10380--99-1086210899110101122105449518
S733GTSDRTTSPEEVHAQ8666--5844--99-6940847684766232194
Y742EEVHAQPYIAIDWEP18--44----------------
S938DVARRLLSPAGSSGA262------36-----------242
S942RLLSPAGSSGAPASP19------------54------
S948GSSGAPASPACSSPP1065216-4535514890-522920184423289367218
S952APASPACSSPPSSEF1028117-12115455-231315142120712612232
S953PASPACSSPPSSEFM916917-1210--18-63101098722410194
S956PACSSPPSSEFMDVN218--------54------54--
Showing 1 to 10 of 11 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S536LSKHTGISPERMMVA-----------
S648RYVTKPNSDDEDDGD1.4e-3--2.6e-6---0.152.4e-132.4e-15-0.27-0.018
S733GTSDRTTSPEEVHAQ-0.75--4.6e-4---6.9e-30.0020.013---
Y742EEVHAQPYIAIDWEP-----------
S938DVARRLLSPAGSSGA-----------
S942RLLSPAGSSGAPASP-----------
S948GSSGAPASPACSSPP-0.86-0.0171--2.8e-30.62--0.3-0.62
S952APASPACSSPPSSEF0.52-----0.27--0.18-3.8e-4-
S953PASPACSSPPSSEFM0.2--------0.2-
S956PACSSPPSSEFMDVN-----------
Showing 1 to 10 of 11 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS536S648S733Y742S938S942S948S952S953S956S957proteinRNASCNVmethylationCCRCCS536S648S733Y742S938S942S948S952S953S956S957proteinRNASCNVmethylationCOADS536S648S733Y742S938S942S948S952S953S956S957proteinRNASCNVmethylationGBMS536S648S733Y742S938S942S948S952S953S956S957proteinRNASCNVmethylationHNSCCS536S648S733Y742S938S942S948S952S953S956S957proteinRNASCNVmethylationLSCCS536S648S733Y742S938S942S948S952S953S956S957proteinRNASCNVmethylationLUADS536S648S733Y742S938S942S948S952S953S956S957proteinRNASCNVmethylationOVS536S648S733Y742S938S942S948S952S953S956S957proteinRNASCNVmethylationPDACS536S648S733Y742S938S942S948S952S953S956S957proteinRNASCNVmethylationUCECS536S648S733Y742S938S942S948S952S953S956S957proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.