Protein: ENSP00000219097
Gene: ORC6

LinkedOmicsKB © 2022-2023 Zhang Lab

ORC6:
origin recognition complex subunit 6

Lollipop plot

Phosphosites location and occurrence

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* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T195REPGDVATPPRKRKK101027104-2727201681-965588781069578156725463
Showing 1 to 1 of 1 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T195REPGDVATPPRKRKK3.8e-63-2.7e-68.3e-5-4.5e-154.5e-257.1e-260.0163.4e-6-
Showing 1 to 1 of 1 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_E2F_TARGETST1952.6e-852.2e-166.5e-40.161.7e-62.2e-162.2e-162.2e-162.5e-32.2e-162.2e-16
HALLMARK_G2M_CHECKPOINTT1954.5e-842.2e-165.6e-30.113.2e-72.2e-162.2e-162.2e-166.7e-32.2e-162.2e-16
HALLMARK_SPERMATOGENESIST1951.3e-542.2e-160.180.141.1e-82.2e-162.2e-162.2e-160.0364.9e-33.3e-3
KINASE-PSP_CDK2T1958.5e-532.2e-160.0438.2e-33.1e-82.2e-162.8e-62.2e-160.682.3e-52.6e-5
HALLMARK_MYC_TARGETS_V2T1951.2e-412.2e-160.049-0.270.0722.7e-102.2e-166.5e-90.0123.9e-43.7e-8
KINASE-PSP_CDK1T1951.6e-372.2e-160.175.1e-33.9e-41.9e-71.2e-52.2e-160.140.0010.045
HALLMARK_MYC_TARGETS_V1T1951.7e-323.4e-93.9e-30.960.0565.7e-52.2e-167.9e-100.385.2e-55.3e-4
xcell: T cell CD4+ Th2T1951.3e-302.7e-123.1e-30.0598.7e-40.0463.1e-55.2e-70.368.9e-52.2e-7
HALLMARK_DNA_REPAIRT1952.4e-309.2e-43.2e-30.640.089.3e-82.2e-161.9e-50.175.4e-44.5e-7
PERT-PSP_NOCODAZOLET1959.7e-308.1e-150.0980.240.16.9e-71.9e-62.2e-160.29.8e-30.076
Showing 1 to 10 of 258 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAT195proteinRNASCNVmethylationCCRCCT195proteinRNASCNVmethylationCOADT195proteinRNASCNVmethylationGBMT195proteinRNASCNVmethylationHNSCCT195proteinRNASCNVmethylationLSCCT195proteinRNASCNVmethylationLUADT195proteinRNASCNVmethylationOVT195proteinRNASCNVmethylationPDACT195proteinRNASCNVmethylationUCECT195proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
CDK1T1951.6e-732.2e-160.0120.17.2e-62.2e-162.2e-162.2e-168.7e-32.2e-164.8e-7
AURKBT1956.4e-632.2e-160.14-0.0942.2e-162.2e-162.2e-160.022.1e-42.2e-16
CHEK1T1955.1e-502.2e-160.051-4.2e-42.9e-73.1e-102.2e-160.060.232.2e-16
VRK1T1951.3e-445.2e-70.360.416.5e-71.1e-72.2e-162.2e-160.314.1e-71.6e-6
PBKT1952.1e-442.2e-160.440.293.2e-64.9e-99.2e-102.2e-160.0030.0186.4e-5
TTKT1952.3e-332.2e-16-0.9-0.442.3e-62.2e-164.6e-61.4e-30.0291.3e-5
CDK2T1952.9e-321.2e-70.020.0220.14.4e-91.5e-94.9e-90.0340.184.3e-6
BUB1BT1951.1e-313.6e-110.24-1.2e-55.4e-81.3e-85.8e-60.045-0.991.2e-7
BAZ1AT1951.1e-286.7e-110.280.360.0871.4e-51e-78.7e-7-6.9e-65.5e-5
CITT1951.6e-283.7e-80.810.261.9e-32.2e-162.2e-16-0.120.0632.2e-43.4e-6
Showing 1 to 10 of 538 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
TNS2T195-5.9e-28-3e-7-1.3e-3-0.43-0.31-9.9e-3-2.2e-16-2.2e-16-0.23-0.058-0.016
LHPPT195-2.2e-25-4.1e-9-0.59-0.55-0.049-3.1e-4-2.6e-8-1.1e-9-0.22-5.1e-4-6.6e-5
PHPT1T195-1.4e-18-3.5e-6-0.32-0.390.95-2.1e-4-2.2e-16-2.8e-3-0.16-5.3e-5-0.3
SSH3T195-1.4e-17-2.2e-160.6-0.89-0.019-7.1e-4-6.8e-3-2.5e-6-0.07-0.067-0.018
HDHD2T195-2.8e-17-3.9e-5-0.12-0.071-0.07-2.1e-3-2.2e-5-1.6e-5-0.34-6.4e-3-0.033
MTM1T195-3.4e-14-0.63-0.24-0.57-8.5e-3-7.6e-4-3.2e-5-3.1e-8-0.1-0.19-1.8e-3
INPP4BT195-4.1e-14-3.5e-10-0.64-0.17-0.16-1.5e-3-4.5e-70.71-0.09-0.2-3.6e-4
DUSP22T195-6e-14-0.51-0.073-0.37-6.6e-4-5.4e-5-1.0e-4-2.5e-8-0.25-0.1-0.47
PTPN23T195-1.7e-13-1.6e-8-0.41-0.90.077-4.5e-5-5.4e-5-6.3e-8-0.64-1.4e-3-0.2
FBP1T195-2.5e-13-4.2e-5-0.38-0.11-9.2e-4-0.046-2.1e-3-0.034-0.35-0.056-1.2e-3
Showing 1 to 10 of 240 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.