USP10: ubiquitin specific peptidase 10
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S27 QFFVTPRS SVELPPY 2 29 - - - - - - - - - - - - 4 4 - - - - 19 2 S28 FFVTPRSS VELPPYS 10 911 41 - 70 64 4 5 72 - 103 59 59 57 102 92 7 1 66 29 64 16 S68 VDEVIEPS DTLPRTP 2 17 7 - - - - - - - 6 4 - - - - - - - - - - T74 PSDTLPRT PSYSISS 10 949 46 - 62 51 28 35 27 - 102 59 88 81 97 87 59 15 24 11 59 18 S76 DTLPRTPS YSISSTL 10 1335 108 - 90 70 77 75 71 - 80 45 108 95 110 100 66 15 97 41 71 16 Y77 TLPRTPSY SISSTLN 1 19 - - - - - - - - 11 8 - - - - - - - - - - S78 LPRTPSYS ISSTLNP 1 21 21 - - - - - - - - - - - - - - - - - - - S80 RTPSYSIS STLNPQA 6 154 30 - 22 20 - - - - 20 7 15 15 9 9 - - - - 7 - T82 PSYSISST LNPQAPE 3 27 - - 5 4 - - - - 6 4 - - - - - - 5 3 - - S97 FILGCTAS KITPDGI 3 52 16 - 4 4 - - - - - - 15 13 - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S27 QFFVTPRS SVELPPY - - - - - - - - - - - S28 FFVTPRSS VELPPYS 0.54 - 1.5e-12 - - -0.46 -6.3e-3 0.15 - -8.3e-6 0.36 S68 VDEVIEPS DTLPRTP - - - - - - - - - - - T74 PSDTLPRT PSYSISS -0.24 - 5.3e-7 -8.3e-5 - -7.6e-15 3.3e-3 2.1e-7 0.51 -0.74 0.11 S76 DTLPRTPS YSISSTL 9.5e-30 - -5.5e-3 1.7e-8 - 6.7e-9 2.9e-27 5.3e-17 0.23 1.0e-6 -0.057 Y77 TLPRTPSY SISSTLN - - - - - - - - - - - S78 LPRTPSYS ISSTLNP - - - - - - - - - - - S80 RTPSYSIS STLNPQA -0.52 - -0.52 - - - - - - - - T82 PSYSISST LNPQAPE - - - - - - - - - - - S97 FILGCTAS KITPDGI - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S27
S28
S68
T74
S76
Y77
S78
S80
T82
S97
T100
S109
Y110
S112
S120
S190
T205
T208
S211
S215
T216
S218
S220
S226
S341
S355
T362
S365
S370
S374
S514
S547
S549
S556
S563
S576
T600
S718
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S27 S28 S68 T74 S76 Y77 S78 S80 T82 S97 T100 S109 Y110 S112 S120 S190 T205 T208 S211 S215 T216 S218 S220 S226 S341 S355 T362 S365 S370 S374 S514 S547 S549 S556 S563 S576 T600 S718 protein RNA SCNV methylation CCRCC S27 S28 S68 T74 S76 Y77 S78 S80 T82 S97 T100 S109 Y110 S112 S120 S190 T205 T208 S211 S215 T216 S218 S220 S226 S341 S355 T362 S365 S370 S374 S514 S547 S549 S556 S563 S576 T600 S718 protein RNA SCNV methylation COAD S27 S28 S68 T74 S76 Y77 S78 S80 T82 S97 T100 S109 Y110 S112 S120 S190 T205 T208 S211 S215 T216 S218 S220 S226 S341 S355 T362 S365 S370 S374 S514 S547 S549 S556 S563 S576 T600 S718 protein RNA SCNV methylation GBM S27 S28 S68 T74 S76 Y77 S78 S80 T82 S97 T100 S109 Y110 S112 S120 S190 T205 T208 S211 S215 T216 S218 S220 S226 S341 S355 T362 S365 S370 S374 S514 S547 S549 S556 S563 S576 T600 S718 protein RNA SCNV methylation HNSCC S27 S28 S68 T74 S76 Y77 S78 S80 T82 S97 T100 S109 Y110 S112 S120 S190 T205 T208 S211 S215 T216 S218 S220 S226 S341 S355 T362 S365 S370 S374 S514 S547 S549 S556 S563 S576 T600 S718 protein RNA SCNV methylation LSCC S27 S28 S68 T74 S76 Y77 S78 S80 T82 S97 T100 S109 Y110 S112 S120 S190 T205 T208 S211 S215 T216 S218 S220 S226 S341 S355 T362 S365 S370 S374 S514 S547 S549 S556 S563 S576 T600 S718 protein RNA SCNV methylation LUAD S27 S28 S68 T74 S76 Y77 S78 S80 T82 S97 T100 S109 Y110 S112 S120 S190 T205 T208 S211 S215 T216 S218 S220 S226 S341 S355 T362 S365 S370 S374 S514 S547 S549 S556 S563 S576 T600 S718 protein RNA SCNV methylation OV S27 S28 S68 T74 S76 Y77 S78 S80 T82 S97 T100 S109 Y110 S112 S120 S190 T205 T208 S211 S215 T216 S218 S220 S226 S341 S355 T362 S365 S370 S374 S514 S547 S549 S556 S563 S576 T600 S718 protein RNA SCNV methylation PDAC S27 S28 S68 T74 S76 Y77 S78 S80 T82 S97 T100 S109 Y110 S112 S120 S190 T205 T208 S211 S215 T216 S218 S220 S226 S341 S355 T362 S365 S370 S374 S514 S547 S549 S556 S563 S576 T600 S718 protein RNA SCNV methylation UCEC S27 S28 S68 T74 S76 Y77 S78 S80 T82 S97 T100 S109 Y110 S112 S120 S190 T205 T208 S211 S215 T216 S218 S220 S226 S341 S355 T362 S365 S370 S374 S514 S547 S549 S556 S563 S576 T600 S718 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S27
S28
S68
T74
S76
Y77
S78
S80
T82
S97
T100
S109
Y110
S112
S120
S190
T205
T208
S211
S215
T216
S218
S220
S226
S341
S355
T362
S365
S370
S374
S514
S547
S549
S556
S563
S576
T600
S718
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S27
S28
S68
T74
S76
Y77
S78
S80
T82
S97
T100
S109
Y110
S112
S120
S190
T205
T208
S211
S215
T216
S218
S220
S226
S341
S355
T362
S365
S370
S374
S514
S547
S549
S556
S563
S576
T600
S718
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.