Protein: ENSP00000219476
Gene: TSC2

LinkedOmicsKB © 2022-2023 Zhang Lab

TSC2:
TSC complex subunit 2

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T23KILLGLGTPRPNPRS215--------------72--6-
S664KKTSGPLSPPTGPPG8819--7157--99-975768638680712913829
T760APEGFSRTDLHLAVV19------9-------------
S775PVLTALISYHNYLDK19------9-------------
Y776VLTALISYHNYLDKT19------9-------------
S923LRSNVLLSFDDTPEK8642--7249--99-181050459789133537316
T927VLLSFDDTPEKDSFR352------26-----10871----
S932DDTPEKDSFRARSTS237------9-----------235
S937KDSFRARSTSLNERP241------35-----------6-
S939SFRARSTSLNERPKS8698--2112--63-31197972676062149137637
Showing 1 to 10 of 57 rows
102550100
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T23KILLGLGTPRPNPRS-----------
S664KKTSGPLSPPTGPPG-2.4e-6-0.73---0.79-1.3e-3-1.0e-6--0.012-
T760APEGFSRTDLHLAVV-----------
S775PVLTALISYHNYLDK-----------
Y776VLTALISYHNYLDKT-----------
S923LRSNVLLSFDDTPEK-0.5-3.9e-13----2.4e-90.047---3.6e-6
T927VLLSFDDTPEKDSFR-----------
S932DDTPEKDSFRARSTS-----------
S937KDSFRARSTSLNERP-----------
S939SFRARSTSLNERPKS-3.7e-9-0.67--0.48-2.1e-12-0.26-0.65-2.7e-12-
Showing 1 to 10 of 57 rows
102550100
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAT23S664T760S775Y776S923T927S932S937S939S960S981S994T996S999S1002S1007S1079S1090S1096S1097S1121S1130S1132S1155S1252S1254S1336S1337S1338S1340S1341S1346S1364S1365S1371S1375S1383S1385S1386S1387S1388T1393S1411S1418S1420T1422S1447S1448S1449S1452T1462S1469T1780S1798S1799T1804proteinRNASCNVmethylationCCRCCT23S664T760S775Y776S923T927S932S937S939S960S981S994T996S999S1002S1007S1079S1090S1096S1097S1121S1130S1132S1155S1252S1254S1336S1337S1338S1340S1341S1346S1364S1365S1371S1375S1383S1385S1386S1387S1388T1393S1411S1418S1420T1422S1447S1448S1449S1452T1462S1469T1780S1798S1799T1804proteinRNASCNVmethylationCOADT23S664T760S775Y776S923T927S932S937S939S960S981S994T996S999S1002S1007S1079S1090S1096S1097S1121S1130S1132S1155S1252S1254S1336S1337S1338S1340S1341S1346S1364S1365S1371S1375S1383S1385S1386S1387S1388T1393S1411S1418S1420T1422S1447S1448S1449S1452T1462S1469T1780S1798S1799T1804proteinRNASCNVmethylationGBMT23S664T760S775Y776S923T927S932S937S939S960S981S994T996S999S1002S1007S1079S1090S1096S1097S1121S1130S1132S1155S1252S1254S1336S1337S1338S1340S1341S1346S1364S1365S1371S1375S1383S1385S1386S1387S1388T1393S1411S1418S1420T1422S1447S1448S1449S1452T1462S1469T1780S1798S1799T1804proteinRNASCNVmethylationHNSCCT23S664T760S775Y776S923T927S932S937S939S960S981S994T996S999S1002S1007S1079S1090S1096S1097S1121S1130S1132S1155S1252S1254S1336S1337S1338S1340S1341S1346S1364S1365S1371S1375S1383S1385S1386S1387S1388T1393S1411S1418S1420T1422S1447S1448S1449S1452T1462S1469T1780S1798S1799T1804proteinRNASCNVmethylationLSCCT23S664T760S775Y776S923T927S932S937S939S960S981S994T996S999S1002S1007S1079S1090S1096S1097S1121S1130S1132S1155S1252S1254S1336S1337S1338S1340S1341S1346S1364S1365S1371S1375S1383S1385S1386S1387S1388T1393S1411S1418S1420T1422S1447S1448S1449S1452T1462S1469T1780S1798S1799T1804proteinRNASCNVmethylationLUADT23S664T760S775Y776S923T927S932S937S939S960S981S994T996S999S1002S1007S1079S1090S1096S1097S1121S1130S1132S1155S1252S1254S1336S1337S1338S1340S1341S1346S1364S1365S1371S1375S1383S1385S1386S1387S1388T1393S1411S1418S1420T1422S1447S1448S1449S1452T1462S1469T1780S1798S1799T1804proteinRNASCNVmethylationOVT23S664T760S775Y776S923T927S932S937S939S960S981S994T996S999S1002S1007S1079S1090S1096S1097S1121S1130S1132S1155S1252S1254S1336S1337S1338S1340S1341S1346S1364S1365S1371S1375S1383S1385S1386S1387S1388T1393S1411S1418S1420T1422S1447S1448S1449S1452T1462S1469T1780S1798S1799T1804proteinRNASCNVmethylationPDACT23S664T760S775Y776S923T927S932S937S939S960S981S994T996S999S1002S1007S1079S1090S1096S1097S1121S1130S1132S1155S1252S1254S1336S1337S1338S1340S1341S1346S1364S1365S1371S1375S1383S1385S1386S1387S1388T1393S1411S1418S1420T1422S1447S1448S1449S1452T1462S1469T1780S1798S1799T1804proteinRNASCNVmethylationUCECT23S664T760S775Y776S923T927S932S937S939S960S981S994T996S999S1002S1007S1079S1090S1096S1097S1121S1130S1132S1155S1252S1254S1336S1337S1338S1340S1341S1346S1364S1365S1371S1375S1383S1385S1386S1387S1388T1393S1411S1418S1420T1422S1447S1448S1449S1452T1462S1469T1780S1798S1799T1804proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.