AGO2: argonaute RISC catalytic component 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
3luc chain A
3luc chain B
3luc chain C
3lud chain A
3lud chain B
3lud chain C
3lug chain A
3lug chain B
3lug chain C
3luh chain A
3luh chain B
3luh chain C
3luj chain A
3luj chain B
3luj chain C
3luk chain A
3luk chain B
3luk chain C
3qx8 chain A
3qx8 chain B
3qx8 chain C
3qx9 chain A
3qx9 chain B
3qx9 chain C
4f3t chain A
4ola chain A
4olb chain A
4w5n chain A
4w5o chain A
4w5q chain A
4w5r chain A
4w5t chain A
4z4c chain A
4z4d chain A
4z4e chain A
4z4f chain A
4z4g chain A
4z4h chain A
4z4i chain A
5js1 chain A
5js2 chain A
5ki6 chain A
5t7b chain A
5wea chain A
6cbd chain A
6mdz chain A
6mdz chain B
6mfn chain A
6mfr chain A
6mfr chain B
6n4o chain A
6nit chain A
6nit chain B
6ra4 chain A
6ra4 chain B
7c6b chain A
7c6b chain B
7c6b chain C
7d7u chain A
7d7u chain B
7d7u chain C
7ki3 chain A
7ki3 chain D
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S387 SKLMRSAS FNTDPYV 5 130 - - - - 9 9 26 - - - - - - - 15 2 6 2 54 7 T390 MRSASFNT DPYVREF 6 91 18 - 4 4 - - - - 24 12 5 5 8 8 - - 2 1 - - S824 LVDKEHDS AEGSHTS 8 130 9 - 8 8 9 9 36 - 5 3 10 7 - - - - 10 4 12 - S828 EHDSAEGS HTSGQSN 8 242 9 - 62 58 - - 18 - 11 3 34 28 4 4 3 - 5 3 - - T830 DSAEGSHT SGQSNGR 10 398 86 - 66 62 5 4 9 - 44 26 24 21 18 15 4 - 5 1 5 3 S831 SAEGSHTS GQSNGRD 8 180 63 - 4 3 10 16 18 - - - 19 17 9 8 - - 4 1 5 3 S834 GSHTSGQS NGRDHQA 8 126 30 - 5 4 9 9 9 - 12 7 10 8 10 8 - - 3 2 - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S387 SKLMRSAS FNTDPYV - - - - - - - - - - - T390 MRSASFNT DPYVREF 8.5e-6 - - - - 8.5e-6 - - - - - S824 LVDKEHDS AEGSHTS - - - - - - - - - - - S828 EHDSAEGS HTSGQSN 1.1e-3 - 0.26 - - - 5.3e-4 - - - - T830 DSAEGSHT SGQSNGR 1.8e-7 - 0.28 - - 2.8e-6 1.1e-3 - - - - S831 SAEGSHTS GQSNGRD - - - - - - - - - - - S834 GSHTSGQS NGRDHQA - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S387
T390
S824
S828
T830
S831
S834
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S387 T390 S824 S828 T830 S831 S834 protein RNA SCNV methylation CCRCC S387 T390 S824 S828 T830 S831 S834 protein RNA SCNV methylation COAD S387 T390 S824 S828 T830 S831 S834 protein RNA SCNV methylation GBM S387 T390 S824 S828 T830 S831 S834 protein RNA SCNV methylation HNSCC S387 T390 S824 S828 T830 S831 S834 protein RNA SCNV methylation LSCC S387 T390 S824 S828 T830 S831 S834 protein RNA SCNV methylation LUAD S387 T390 S824 S828 T830 S831 S834 protein RNA SCNV methylation OV S387 T390 S824 S828 T830 S831 S834 protein RNA SCNV methylation PDAC S387 T390 S824 S828 T830 S831 S834 protein RNA SCNV methylation UCEC S387 T390 S824 S828 T830 S831 S834 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S387
T390
S824
S828
T830
S831
S834
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S387
T390
S824
S828
T830
S831
S834
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.