RIPK2: receptor interacting serine/threonine kinase 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2n7z chain A
2n83 chain B
4c8b chain A
4c8b chain B
5ar2 chain A
5ar2 chain B
5ar3 chain A
5ar3 chain B
5ar4 chain A
5ar4 chain B
5ar5 chain A
5ar5 chain B
5ar7 chain A
5ar7 chain B
5ar8 chain A
5ar8 chain B
5j79 chain A
5j79 chain B
5j7b chain A
5j7b chain B
5ng0 chain A
5ng0 chain B
5ng2 chain A
5ng2 chain B
5ng3 chain A
5ng3 chain B
5ng3 chain C
5ng3 chain D
5w5j chain A
5w5j chain B
5w5o chain A
5w5o chain B
5w5o chain C
5w5o chain D
5w5o chain E
5w5o chain F
5w5o chain G
5w5o chain H
5w5o chain I
5w5o chain J
5w5o chain K
5w5o chain L
5w5o chain M
5w5o chain N
5w5o chain O
5w5o chain P
5yrn chain A
5yrn chain B
5yrn chain C
5yrn chain D
5yrn chain E
5yrn chain F
5yrn chain G
5yrn chain H
5yrn chain I
5yrn chain J
5yrn chain K
5yrn chain L
6es0 chain A
6es0 chain B
6fu5 chain A
6fu5 chain B
6gfj chain A
6gfj chain B
6gfj chain C
6gfj chain D
6ggs chain A
6ggs chain B
6ggs chain C
6ggs chain D
6ggs chain E
6ggs chain F
6ggs chain G
6ggs chain H
6ggs chain I
6ggs chain J
6hmx chain A
6hmx chain B
6rn8 chain A
6rn8 chain B
6rna chain A
6rna chain B
6s1f chain A
6s1f chain B
6s1f chain C
6s1f chain D
6sze chain A
6sze chain B
6szj chain A
6szj chain B
6ul8 chain A
6ul8 chain B
7obs chain B
7obt chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S174 LSKWRMMS LSQSRSS 4 106 50 - - - - - - - - - 10 8 - - 22 4 - - 12 - S176 KWRMMSLS QSRSSKS 9 591 96 - 52 32 - - 35 - 11 8 54 48 58 53 22 4 45 20 47 6 S178 RMMSLSQS RSSKSAP 10 1134 105 - 90 68 10 16 90 - 75 42 108 99 89 81 19 6 105 44 72 15 S180 MSLSQSRS SKSAPEG 1 8 - - - - - - - - - - - - - - - - - - 5 3 S183 SQSRSSKS APEGGTI 4 129 9 - - - - - - - - - 5 5 10 8 - - - - 74 18 S319 TKLQSVSS AIHLCDK 9 417 16 - 25 24 - - 18 - 19 9 58 53 56 51 7 1 26 12 40 2 S345 NHGPQEES CGSSQLH 1 9 9 - - - - - - - - - - - - - - - - - - - S348 PQEESCGS SQLHENS 2 34 26 - - - - - - - - - - - 4 4 - - - - - - S349 QEESCGSS QLHENSG 2 23 15 - - - - - - - - - - - 4 4 - - - - - - S357 QLHENSGS PETSRSL 7 230 14 - - - - - 99 - - - 10 10 35 31 7 1 5 1 15 2
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S174 LSKWRMMS LSQSRSS - - - - - - - - - - - S176 KWRMMSLS QSRSSKS 4.9e-3 - 1.7e-6 - - - -0.093 0.51 - 0.063 - S178 RMMSLSQS RSSKSAP 0.14 - 2e-18 - - 2.9e-8 -1.6e-9 -3.7e-6 - -0.031 -5.5e-6 S180 MSLSQSRS SKSAPEG - - - - - - - - - - - S183 SQSRSSKS APEGGTI 1.5e-3 - - - - - - - - - 1.5e-3 S319 TKLQSVSS AIHLCDK 1.3e-3 - -0.6 - - - 5e-7 4.9e-6 - -8.2e-3 - S345 NHGPQEES CGSSQLH - - - - - - - - - - - S348 PQEESCGS SQLHENS - - - - - - - - - - - S349 QEESCGSS QLHENSG - - - - - - - - - - - S357 QLHENSGS PETSRSL -0.33 - - - - - - -0.33 - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S174
S176
S178
S180
S183
S319
S345
S348
S349
S357
S363
S374
Y381
S393
T412
S416
S423
S428
T484
S527
S529
S531
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S174 S176 S178 S180 S183 S319 S345 S348 S349 S357 S363 S374 Y381 S393 T412 S416 S423 S428 T484 S527 S529 S531 protein RNA SCNV methylation CCRCC S174 S176 S178 S180 S183 S319 S345 S348 S349 S357 S363 S374 Y381 S393 T412 S416 S423 S428 T484 S527 S529 S531 protein RNA SCNV methylation COAD S174 S176 S178 S180 S183 S319 S345 S348 S349 S357 S363 S374 Y381 S393 T412 S416 S423 S428 T484 S527 S529 S531 protein RNA SCNV methylation GBM S174 S176 S178 S180 S183 S319 S345 S348 S349 S357 S363 S374 Y381 S393 T412 S416 S423 S428 T484 S527 S529 S531 protein RNA SCNV methylation HNSCC S174 S176 S178 S180 S183 S319 S345 S348 S349 S357 S363 S374 Y381 S393 T412 S416 S423 S428 T484 S527 S529 S531 protein RNA SCNV methylation LSCC S174 S176 S178 S180 S183 S319 S345 S348 S349 S357 S363 S374 Y381 S393 T412 S416 S423 S428 T484 S527 S529 S531 protein RNA SCNV methylation LUAD S174 S176 S178 S180 S183 S319 S345 S348 S349 S357 S363 S374 Y381 S393 T412 S416 S423 S428 T484 S527 S529 S531 protein RNA SCNV methylation OV S174 S176 S178 S180 S183 S319 S345 S348 S349 S357 S363 S374 Y381 S393 T412 S416 S423 S428 T484 S527 S529 S531 protein RNA SCNV methylation PDAC S174 S176 S178 S180 S183 S319 S345 S348 S349 S357 S363 S374 Y381 S393 T412 S416 S423 S428 T484 S527 S529 S531 protein RNA SCNV methylation UCEC S174 S176 S178 S180 S183 S319 S345 S348 S349 S357 S363 S374 Y381 S393 T412 S416 S423 S428 T484 S527 S529 S531 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S174
S176
S178
S180
S183
S319
S345
S348
S349
S357
S363
S374
Y381
S393
T412
S416
S423
S428
T484
S527
S529
S531
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S174
S176
S178
S180
S183
S319
S345
S348
S349
S357
S363
S374
Y381
S393
T412
S416
S423
S428
T484
S527
S529
S531
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.