Protein: ENSP00000225655
Gene: PFN1

LinkedOmicsKB © 2022-2023 Zhang Lab

PFN1:
profilin 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S28AIVGYKDSPSVWAAV84549-5452--63-2214252354--52248918
S30VGYKDSPSVWAAVPG7329------18-27172524716518672445
T39WAAVPGKTFVNITPA5136--88----1711151398----416
T44GKTFVNITPAEVGVL291----------30271816------
S57VLVGKDRSSFYVNGL826442---6326-171030281311--2283711
S58LVGKDRSSFYVNGLT953526-1312--53-3620444159537159266718
T65SFYVNGLTLGGQKCS565--44------10844--52222
S72TLGGQKCSVIRDSLL2526-----46-------------
S77KCSVIRDSLLQDGEF848470-54--27-57307971656271--6-
S85LLQDGEFSMDLRTKS511118-2220------98141253----
Showing 1 to 10 of 17 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S28AIVGYKDSPSVWAAV0.055--0.69---0.170.33--0.0460.002
S30VGYKDSPSVWAAVPG2.5e-4-----0.185.2e-31.0e-6---
T39WAAVPGKTFVNITPA-----------
T44GKTFVNITPAEVGVL0.92-----0.92----
S57VLVGKDRSSFYVNGL9.4e-6-----4.8e-5---0.028
S58LVGKDRSSFYVNGLT8e-10----0.0999.5e-41.7e-3-2.7e-38.3e-3
T65SFYVNGLTLGGQKCS-----------
S72TLGGQKCSVIRDSLL-----------
S77KCSVIRDSLLQDGEF-2.2e-16----0.63-1.2e-17-7.7e-10---
S85LLQDGEFSMDLRTKS0.61-0.61--------
Showing 1 to 10 of 17 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS28S30T39T44S57S58T65S72S77S85S92T93T98T102T104Y129S133proteinRNASCNVmethylationCCRCCS28S30T39T44S57S58T65S72S77S85S92T93T98T102T104Y129S133proteinRNASCNVmethylationCOADS28S30T39T44S57S58T65S72S77S85S92T93T98T102T104Y129S133proteinRNASCNVmethylationGBMS28S30T39T44S57S58T65S72S77S85S92T93T98T102T104Y129S133proteinRNASCNVmethylationHNSCCS28S30T39T44S57S58T65S72S77S85S92T93T98T102T104Y129S133proteinRNASCNVmethylationLSCCS28S30T39T44S57S58T65S72S77S85S92T93T98T102T104Y129S133proteinRNASCNVmethylationLUADS28S30T39T44S57S58T65S72S77S85S92T93T98T102T104Y129S133proteinRNASCNVmethylationOVS28S30T39T44S57S58T65S72S77S85S92T93T98T102T104Y129S133proteinRNASCNVmethylationPDACS28S30T39T44S57S58T65S72S77S85S92T93T98T102T104Y129S133proteinRNASCNVmethylationUCECS28S30T39T44S57S58T65S72S77S85S92T93T98T102T104Y129S133proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.