Protein: ENSP00000225792
Gene: DDX5

LinkedOmicsKB © 2022-2023 Zhang Lab

DDX5:
DEAD-box helicase 5

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S6__MSGYSSDRDRGRD5337----6569--41241514--4793815--
S24GAPRFGGSRAGPLSG11515-------------------
S30GSRAGPLSGKKFGNP969126-6949--81-102584440474414346213611
S79EVETYRRSKEITVRG118----108--------------
S338RLMEEIMSEKENKTI120----------1010--------
S480QLVEDRGSGRSRGRG9105396-99779954-935093869283--78338318
S498DDRRDRYSAGKRGGF5325------81---54--571155237316
S519ENYDRGYSSLLKRDF372----------10101412----242
S520NYDRGYSSLLKRDFG969326-9169--55-1887364605028642157216
S544AANYTNGSFGSNFVS35823-----9-179----------
Showing 1 to 10 of 10 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S6__MSGYSSDRDRGRD0.012--1.4e-3-7.1e-4----0.027-
S24GAPRFGGSRAGPLSG-----------
S30GSRAGPLSGKKFGNP5.1e-7--0.022--4.7e-70.0024.1e-9--0.630.29
S79EVETYRRSKEITVRG-----------
S338RLMEEIMSEKENKTI-----------
S480QLVEDRGSGRSRGRG5.7e-39-0.07--1.7e-76.5e-252e-24-0.581.0e-4
S498DDRRDRYSAGKRGGF-0.12-------0.002-0.31-1.7e-6
S519ENYDRGYSSLLKRDF-----------
S520NYDRGYSSLLKRDFG9.3e-24--0.029---3.3e-176.4e-15-9.6e-97.2e-3
S544AANYTNGSFGSNFVS-----------
Showing 1 to 10 of 10 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS6S24S30S79S338S480S498S519S520S544proteinRNASCNVmethylationCCRCCS6S24S30S79S338S480S498S519S520S544proteinRNASCNVmethylationCOADS6S24S30S79S338S480S498S519S520S544proteinRNASCNVmethylationGBMS6S24S30S79S338S480S498S519S520S544proteinRNASCNVmethylationHNSCCS6S24S30S79S338S480S498S519S520S544proteinRNASCNVmethylationLSCCS6S24S30S79S338S480S498S519S520S544proteinRNASCNVmethylationLUADS6S24S30S79S338S480S498S519S520S544proteinRNASCNVmethylationOVS6S24S30S79S338S480S498S519S520S544proteinRNASCNVmethylationPDACS6S24S30S79S338S480S498S519S520S544proteinRNASCNVmethylationUCECS6S24S30S79S338S480S498S519S520S544proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.