Protein: ENSP00000229328
Gene: PRKAB1

LinkedOmicsKB © 2022-2023 Zhang Lab

PRKAB1:
protein kinase AMP-activated non-catalytic subunit beta 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S24HKTPRRDSSGGTKDG826930-211211753---2523--33952299
S40RPKILMDSPEDADLF877429-9976--71-814588804945--54252111
S49EDADLFHSEEIKAPE88646-7965--81-905473679688--69275613
S96KEVYLSGSFNNWSKL101261113-10380575099-10259108991029320649218515
S101SGSFNNWSKLPLTRS634581-5481027---49446156------
S108SKLPLTRSHNNFVAI101500122-103809710099-1086210899110101469105448918
S138GQWTHDPSEPIVTSQ620418-151563----35283937--62--
T148IVTSQLGTVNNIIQV49813---4131------44--32--
S170FDALMVDSQKCSDVS3109--2926----522423--------
S174MVDSQKCSDVSELSS215--44----52----------
Showing 1 to 10 of 17 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S24HKTPRRDSSGGTKDG-0.72-3.4e-4----4.4e-5----
S40RPKILMDSPEDADLF-9.0e-6-1.0e-4---2.2e-8-3.6e-5-0.24--3.8e-3-1
S49EDADLFHSEEIKAPE-1.4e-23--2.3e-9---2.6e-4-1.2e-14-8.8e-3--2.3e-80.3
S96KEVYLSGSFNNWSKL4.8e-20--1.7e-116.6e-6-1e-115.5e-181.6e-9-3.9e-30.035
S101SGSFNNWSKLPLTRS-0.67-----0.21-0.064---
S108SKLPLTRSHNNFVAI-0.14--3.6e-126.3e-3--1.5e-40.0110.23-2.5e-3-8.6e-3
S138GQWTHDPSEPIVTSQ2.5e-7-----2.1e-32.4e-5---
T148IVTSQLGTVNNIIQV0.007--0.007-------
S170FDALMVDSQKCSDVS-2.5e-3--0.68----1.1e-4----
S174MVDSQKCSDVSELSS-----------
Showing 1 to 10 of 17 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS24S40S49S96S101S108S138T148S170S174S177S180S181S182Y192S222Y240proteinRNASCNVmethylationCCRCCS24S40S49S96S101S108S138T148S170S174S177S180S181S182Y192S222Y240proteinRNASCNVmethylationCOADS24S40S49S96S101S108S138T148S170S174S177S180S181S182Y192S222Y240proteinRNASCNVmethylationGBMS24S40S49S96S101S108S138T148S170S174S177S180S181S182Y192S222Y240proteinRNASCNVmethylationHNSCCS24S40S49S96S101S108S138T148S170S174S177S180S181S182Y192S222Y240proteinRNASCNVmethylationLSCCS24S40S49S96S101S108S138T148S170S174S177S180S181S182Y192S222Y240proteinRNASCNVmethylationLUADS24S40S49S96S101S108S138T148S170S174S177S180S181S182Y192S222Y240proteinRNASCNVmethylationOVS24S40S49S96S101S108S138T148S170S174S177S180S181S182Y192S222Y240proteinRNASCNVmethylationPDACS24S40S49S96S101S108S138T148S170S174S177S180S181S182Y192S222Y240proteinRNASCNVmethylationUCECS24S40S49S96S101S108S138T148S170S174S177S180S181S182Y192S222Y240proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.