Protein: ENSP00000229595
Gene: ASF1A

LinkedOmicsKB © 2022-2023 Zhang Lab

ASF1A:
anti-silencing function 1A histone chaperone

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S165EKLEDAESSNPNLQS568--------635489--32235
S166KLEDAESSNPNLQSL101525122-103809710099-10862108991101016113105449518
S172SSNPNLQSLLSTDAL723967-4627----6324221715--3252
S175PNLQSLLSTDALPSA1084521-7856202463-10259403772646283356518
T176NLQSLLSTDALPSAS6718---279-115--98----12-
S181LSTDALPSASKGWST451--------73109----8311-
S183TDALPSASKGWSTSE7142--54--9-211610844--3113134
S189ASKGWSTSENSLNVM19----------54--------
S192GWSTSENSLNVMLES774099-54--44-98551089910093----2411
S199SLNVMLESHMDCM__24939-------73----------
Showing 1 to 10 of 10 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S165EKLEDAESSNPNLQS-----------
S166KLEDAESSNPNLQSL1.2e-27--8.4e-44.2e-7-9.8e-75.4e-263e-10-0.538.4e-140.6
S172SSNPNLQSLLSTDAL-0.29--9.7e-3---0.27----
S175PNLQSLLSTDALPSA-0.022-4e-7-0.026--2.6e-4-3.5e-3-4.4e-4-1.4e-7-4.9e-5
T176NLQSLLSTDALPSAS-----------
S181LSTDALPSASKGWST-----------
S183TDALPSASKGWSTSE-0.41-----0.032---0.33-
S189ASKGWSTSENSLNVM-----------
S192GWSTSENSLNVMLES6.6e-3----0.282.0e-60.37---0.2
S199SLNVMLESHMDCM__-----------
Showing 1 to 10 of 10 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS165S166S172S175T176S181S183S189S192S199proteinRNASCNVmethylationCCRCCS165S166S172S175T176S181S183S189S192S199proteinRNASCNVmethylationCOADS165S166S172S175T176S181S183S189S192S199proteinRNASCNVmethylationGBMS165S166S172S175T176S181S183S189S192S199proteinRNASCNVmethylationHNSCCS165S166S172S175T176S181S183S189S192S199proteinRNASCNVmethylationLSCCS165S166S172S175T176S181S183S189S192S199proteinRNASCNVmethylationLUADS165S166S172S175T176S181S183S189S192S199proteinRNASCNVmethylationOVS165S166S172S175T176S181S183S189S192S199proteinRNASCNVmethylationPDACS165S166S172S175T176S181S183S189S192S199proteinRNASCNVmethylationUCECS165S166S172S175T176S181S183S189S192S199proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.