Protein: ENSP00000233027
Gene: NEK4

LinkedOmicsKB © 2022-2023 Zhang Lab

NEK4:
NIMA related kinase 4

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S340RASGLLKSPASLKAH312262---1413--------285----
S377LPAKGRDSVSDGFVQ6122--54179---1092723234----
S457EQKPKDQSLALSPKL121------------------192
S461KDQSLALSPKLECSG9100588-7453--99-161193851069727796409518
S481SNLRLLGSSDSPASA114------------------122
S526PDLQPHNSGSEPSLS4588-----36---44------6-
S563DLFAFQESPPRFLPS1092670-3229564380-49286964887982181799518
S596QRRVVTGSVSSSRSS118------18-------------
S614SSKDRPLSARERRRL19------9-------------
S639GPSVRKASLSVAGPG8436----342999-161129274415251207916
Showing 1 to 10 of 19 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S340RASGLLKSPASLKAH-----------
S377LPAKGRDSVSDGFVQ9.9e-4------9.9e-4---
S457EQKPKDQSLALSPKL-----------
S461KDQSLALSPKLECSG-0.046-0.97----7.5e-50.33--1.1e-107.9e-7
S481SNLRLLGSSDSPASA-----------
S526PDLQPHNSGSEPSLS-----------
S563DLFAFQESPPRFLPS8.4e-5--5.0e-40.38-0.335.5e-32.0e-60.35-3.4e-4
S596QRRVVTGSVSSSRSS-----------
S614SSKDRPLSARERRRL-----------
S639GPSVRKASLSVAGPG-0.12---1.4e-6---0.78--4.0e-5-0.037
Showing 1 to 10 of 19 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS340S377S457S461S481S526S563S596S614S639S641S661S662S677S691T702S720S723S772proteinRNASCNVmethylationCCRCCS340S377S457S461S481S526S563S596S614S639S641S661S662S677S691T702S720S723S772proteinRNASCNVmethylationCOADS340S377S457S461S481S526S563S596S614S639S641S661S662S677S691T702S720S723S772proteinRNASCNVmethylationGBMS340S377S457S461S481S526S563S596S614S639S641S661S662S677S691T702S720S723S772proteinRNASCNVmethylationHNSCCS340S377S457S461S481S526S563S596S614S639S641S661S662S677S691T702S720S723S772proteinRNASCNVmethylationLSCCS340S377S457S461S481S526S563S596S614S639S641S661S662S677S691T702S720S723S772proteinRNASCNVmethylationLUADS340S377S457S461S481S526S563S596S614S639S641S661S662S677S691T702S720S723S772proteinRNASCNVmethylationOVS340S377S457S461S481S526S563S596S614S639S641S661S662S677S691T702S720S723S772proteinRNASCNVmethylationPDACS340S377S457S461S481S526S563S596S614S639S641S661S662S677S691T702S720S723S772proteinRNASCNVmethylationUCECS340S377S457S461S481S526S563S596S614S639S641S661S662S677S691T702S720S723S772proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.