Protein: ENSP00000233057
Gene: EIF2AK2

LinkedOmicsKB © 2022-2023 Zhang Lab

EIF2AK2:
eukaryotic translation initiation factor 2 alpha kinase 2

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T16FFMEELNTYRQKQGV19----------------72--
Y17FMEELNTYRQKQGVV19----------------72--
S33KYQELPNSGPPHDRR478------9-521513--286----
S83NKEKKAVSPLLLTTT101245113-8368494080-108621069911010135756238916
T89VSPLLLTTTNSSEGL214--33----53----------
T90SPLLLTTTNSSEGLS19----------54--------
S92LLLTTTNSSEGLSMG1083829-7252414870-10355483790802-33134916
S93LLTTTNSSEGLSMGN219------9---55--------
S97TNSSEGLSMGNYIGL3166-------52------21--
S143KMGQKEYSIGTGSTK118------18-------------
Showing 1 to 10 of 23 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T16FFMEELNTYRQKQGV-----------
Y17FMEELNTYRQKQGVV-----------
S33KYQELPNSGPPHDRR-----------
S83NKEKKAVSPLLLTTT1.4e-9-5.8e-4-8.4e-3-0.141.6e-71.9e-3-4.6e-30.011
T89VSPLLLTTTNSSEGL-----------
T90SPLLLTTTNSSEGLS-----------
S92LLLTTTNSSEGLSMG2.2e-7-0.018-5.4e-3-4.1e-53.5e-90.42-0.330.019
S93LLTTTNSSEGLSMGN-----------
S97TNSSEGLSMGNYIGL-----------
S143KMGQKEYSIGTGSTK-----------
Showing 1 to 10 of 23 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAT16Y17S33S83T89T90S92S93S97S143S148S171S242T336S337S340S407T437S438S456T529S530S542proteinRNASCNVmethylationCCRCCT16Y17S33S83T89T90S92S93S97S143S148S171S242T336S337S340S407T437S438S456T529S530S542proteinRNASCNVmethylationCOADT16Y17S33S83T89T90S92S93S97S143S148S171S242T336S337S340S407T437S438S456T529S530S542proteinRNASCNVmethylationGBMT16Y17S33S83T89T90S92S93S97S143S148S171S242T336S337S340S407T437S438S456T529S530S542proteinRNASCNVmethylationHNSCCT16Y17S33S83T89T90S92S93S97S143S148S171S242T336S337S340S407T437S438S456T529S530S542proteinRNASCNVmethylationLSCCT16Y17S33S83T89T90S92S93S97S143S148S171S242T336S337S340S407T437S438S456T529S530S542proteinRNASCNVmethylationLUADT16Y17S33S83T89T90S92S93S97S143S148S171S242T336S337S340S407T437S438S456T529S530S542proteinRNASCNVmethylationOVT16Y17S33S83T89T90S92S93S97S143S148S171S242T336S337S340S407T437S438S456T529S530S542proteinRNASCNVmethylationPDACT16Y17S33S83T89T90S92S93S97S143S148S171S242T336S337S340S407T437S438S456T529S530S542proteinRNASCNVmethylationUCECT16Y17S33S83T89T90S92S93S97S143S148S171S242T336S337S340S407T437S438S456T529S530S542proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.