SORBS3: sorbin and SH3 domain containing 3
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2ct3 chain A
2dlm chain A
2nwm chain A
2yup chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S13 RSLRAGLS LDDFIPG 7 521 35 - 29 17 - - 98 - 108 62 28 26 55 47 13 3 - - - - S24 FIPGHLQS HIGSSSR 1 9 - - - - - - - - - - 5 4 - - - - - - - - T64 TVCNGGYT PRRDASQ 6 147 - - 16 8 - - - - 5 3 19 16 31 28 7 2 - - 12 - S70 YTPRRDAS QHPDPAW 1 9 - - - - - - 9 - - - - - - - - - - - - - T80 PDPAWYQT WPGPGSK 7 459 88 - 41 23 - - 82 - 85 49 15 12 13 12 - - 28 11 - - S104 SQHTQNWS ATWTKDS 4 103 62 - - - 14 13 - - 5 3 - - - - - - 4 2 - - T106 HTQNWSAT WTKDSKR 2 62 - - - - - - 53 - - - - - - - 7 2 - - - - S111 SATWTKDS KRRDKRW 1 9 - - - - - - 9 - - - - - - - - - - - - - S139 MPIAPRSS VDRPRDW 8 467 15 - 62 43 47 52 27 - - - 20 20 37 37 61 14 - - 30 2 T191 AHRPGPAT SSSGRSW 2 59 - - 21 20 - - 18 - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S13 RSLRAGLS LDDFIPG -4e-13 - 1.1e-4 - - -3.5e-14 -4.8e-5 -1.7e-11 - - - S24 FIPGHLQS HIGSSSR - - - - - - - - - - - T64 TVCNGGYT PRRDASQ -0.35 - - - - - - -0.35 - - - S70 YTPRRDAS QHPDPAW - - - - - - - - - - - T80 PDPAWYQT WPGPGSK -6.5e-5 - 5.5e-6 - - -1.9e-16 - - - -1.2e-3 - S104 SQHTQNWS ATWTKDS - - - - - - - - - - - T106 HTQNWSAT WTKDSKR - - - - - - - - - - - S111 SATWTKDS KRRDKRW - - - - - - - - - - - S139 MPIAPRSS VDRPRDW -7.1e-16 - 1.1e-4 -2.6e-5 - - -1.5e-11 -1.6e-14 -1.1e-3 - - T191 AHRPGPAT SSSGRSW 0.73 - 0.73 - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S13
S24
T64
S70
T80
S104
T106
S111
S139
T191
S192
S194
S197
S241
S283
S299
S303
S348
S366
S368
S373
S395
Y408
T529
S530
S539
S544
S545
S547
S551
T562
S563
S570
T580
T585
S591
S593
S597
S605
S606
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S13 S24 T64 S70 T80 S104 T106 S111 S139 T191 S192 S194 S197 S241 S283 S299 S303 S348 S366 S368 S373 S395 Y408 T529 S530 S539 S544 S545 S547 S551 T562 S563 S570 T580 T585 S591 S593 S597 S605 S606 protein RNA SCNV methylation CCRCC S13 S24 T64 S70 T80 S104 T106 S111 S139 T191 S192 S194 S197 S241 S283 S299 S303 S348 S366 S368 S373 S395 Y408 T529 S530 S539 S544 S545 S547 S551 T562 S563 S570 T580 T585 S591 S593 S597 S605 S606 protein RNA SCNV methylation COAD S13 S24 T64 S70 T80 S104 T106 S111 S139 T191 S192 S194 S197 S241 S283 S299 S303 S348 S366 S368 S373 S395 Y408 T529 S530 S539 S544 S545 S547 S551 T562 S563 S570 T580 T585 S591 S593 S597 S605 S606 protein RNA SCNV methylation GBM S13 S24 T64 S70 T80 S104 T106 S111 S139 T191 S192 S194 S197 S241 S283 S299 S303 S348 S366 S368 S373 S395 Y408 T529 S530 S539 S544 S545 S547 S551 T562 S563 S570 T580 T585 S591 S593 S597 S605 S606 protein RNA SCNV methylation HNSCC S13 S24 T64 S70 T80 S104 T106 S111 S139 T191 S192 S194 S197 S241 S283 S299 S303 S348 S366 S368 S373 S395 Y408 T529 S530 S539 S544 S545 S547 S551 T562 S563 S570 T580 T585 S591 S593 S597 S605 S606 protein RNA SCNV methylation LSCC S13 S24 T64 S70 T80 S104 T106 S111 S139 T191 S192 S194 S197 S241 S283 S299 S303 S348 S366 S368 S373 S395 Y408 T529 S530 S539 S544 S545 S547 S551 T562 S563 S570 T580 T585 S591 S593 S597 S605 S606 protein RNA SCNV methylation LUAD S13 S24 T64 S70 T80 S104 T106 S111 S139 T191 S192 S194 S197 S241 S283 S299 S303 S348 S366 S368 S373 S395 Y408 T529 S530 S539 S544 S545 S547 S551 T562 S563 S570 T580 T585 S591 S593 S597 S605 S606 protein RNA SCNV methylation OV S13 S24 T64 S70 T80 S104 T106 S111 S139 T191 S192 S194 S197 S241 S283 S299 S303 S348 S366 S368 S373 S395 Y408 T529 S530 S539 S544 S545 S547 S551 T562 S563 S570 T580 T585 S591 S593 S597 S605 S606 protein RNA SCNV methylation PDAC S13 S24 T64 S70 T80 S104 T106 S111 S139 T191 S192 S194 S197 S241 S283 S299 S303 S348 S366 S368 S373 S395 Y408 T529 S530 S539 S544 S545 S547 S551 T562 S563 S570 T580 T585 S591 S593 S597 S605 S606 protein RNA SCNV methylation UCEC S13 S24 T64 S70 T80 S104 T106 S111 S139 T191 S192 S194 S197 S241 S283 S299 S303 S348 S366 S368 S373 S395 Y408 T529 S530 S539 S544 S545 S547 S551 T562 S563 S570 T580 T585 S591 S593 S597 S605 S606 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S13
S24
T64
S70
T80
S104
T106
S111
S139
T191
S192
S194
S197
S241
S283
S299
S303
S348
S366
S368
S373
S395
Y408
T529
S530
S539
S544
S545
S547
S551
T562
S563
S570
T580
T585
S591
S593
S597
S605
S606
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S13
S24
T64
S70
T80
S104
T106
S111
S139
T191
S192
S194
S197
S241
S283
S299
S303
S348
S366
S368
S373
S395
Y408
T529
S530
S539
S544
S545
S547
S551
T562
S563
S570
T580
T585
S591
S593
S597
S605
S606
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.