- TWIST1:
- twist family bHLH transcription factor 1
Lollipop plot
Phosphosites location and occurrence
Structure
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Site
| Sequence | Cohorts | Total | T | N | T | N | T | N | T | N | T | N | T | N | T | N | T | N | T | N | T | N |
S45 | KRRSSRRSAGGGAGP | 4 | 51 | - | - | - | - | - | - | 9 | - | 12 | 6 | 5 | 5 | - | - | - | - | - | - | 11 | 3 |
S68 | GGGDEPGSPAQGKRG | 9 | 932 | 122 | - | - | - | 27 | 18 | 62 | - | 108 | 62 | 108 | 96 | 26 | 23 | 52 | 13 | 71 | 31 | 95 | 18 |
S94 | AGGGGGSSSGGGSPQ | 1 | 10 | - | - | - | - | - | - | - | - | - | - | 5 | 5 | - | - | - | - | - | - | - | - |
S99 | GSSSGGGSPQSYEEL | 5 | 47 | 8 | - | - | - | - | - | - | - | 10 | 7 | 5 | 4 | - | - | - | - | 4 | 1 | 5 | 3 |
Tumor and normal comparison
Site
| Sequence | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
---|---|---|---|---|---|---|---|---|---|---|---|---|
S45 | KRRSSRRSAGGGAGP | - | - | - | - | - | - | - | - | - | - | - |
S68 | GGGDEPGSPAQGKRG | 2.4e-7 | - | - | 0.003 | - | -9.5e-4 | 1.7e-28 | 1.6e-6 | -0.33 | 5.7e-5 | -8.5e-7 |
S94 | AGGGGGSSSGGGSPQ | - | - | - | - | - | - | - | - | - | - | - |
S99 | GSSSGGGSPQSYEEL | - | - | - | - | - | - | - | - | - | - | - |
Phenotype and mutation association
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION | S68 | 2.1e-28 | 3.4e-7 | - | 0.32 | 6.3e-3 | 3.5e-7 | 2.4e-9 | 0.21 | 0.02 | 4.2e-6 | 3.6e-7 |
PROGENy: TGFb | S68 | 3.9e-26 | 1.1e-7 | - | 0.35 | 4.9e-3 | 2.8e-7 | 1.5e-8 | 0.3 | 0.036 | 5.6e-4 | 1.2e-7 |
ESTIMATE: StromalScore | S68 | 2.1e-19 | 4.2e-7 | - | 0.66 | 0.038 | 2.3e-5 | 2.9e-4 | 0.12 | 0.056 | 2.9e-4 | 7.3e-6 |
HALLMARK_UV_RESPONSE_DN | S68 | 2.2e-18 | 8.8e-7 | - | -0.79 | 0.076 | 1.2e-8 | 1.1e-5 | 0.74 | 0.12 | 0.042 | 8.1e-9 |
HALLMARK_ANGIOGENESIS | S68 | 5.6e-16 | 8e-9 | - | 0.069 | 0.087 | 1.4e-4 | 8.5e-4 | 0.42 | 0.29 | 0.022 | 2.2e-4 |
HALLMARK_APICAL_JUNCTION | S68 | 4.6e-14 | 2.2e-5 | - | 1 | 4.6e-3 | 0.23 | 2.8e-6 | 0.084 | 0.17 | 0.049 | 0.001 |
xcell: Cancer associated fibroblast | S68 | 8.6e-12 | 2.3e-6 | - | 0.35 | 0.01 | 4.8e-3 | 0.074 | 0.66 | 0.6 | 1 | 2.3e-11 |
xcell: stroma score | S68 | 1.9e-11 | 7.3e-7 | - | 0.26 | 0.18 | 0.021 | 0.1 | -0.76 | 0.37 | -0.98 | 2.2e-16 |
HALLMARK_COAGULATION | S68 | 1e-10 | 3.7e-5 | - | 0.27 | 0.024 | 3.1e-3 | 0.074 | -0.65 | 0.12 | 0.013 | 3.6e-4 |
HALLMARK_MYOGENESIS | S68 | 3.3e-9 | 1.3e-5 | - | 0.48 | 0.16 | -0.86 | 1.1e-3 | -0.74 | 0.063 | 0.09 | 6.6e-7 |
Cis-association
Kinase association
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Kinase | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
No matching records found |
Phosphatase association
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphatase | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
No matching records found |