Protein: ENSP00000244741
Gene: CDKN1A

LinkedOmicsKB © 2022-2023 Zhang Lab

CDKN1A:
cyclin dependent kinase inhibitor 1A

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S31PVDSEQLSRDCDALM127--------------225----
S114EEDHVDLSLSCTLVP18--------53----------
S130SGEQAEGSPGGPGDS10105495-5336767699-10359103947768152239606
Showing 1 to 3 of 3 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S31PVDSEQLSRDCDALM-----------
S114EEDHVDLSLSCTLVP-----------
S130SGEQAEGSPGGPGDS5.8e-67-1.7e-118.5e-8-1.1e-171.7e-202.5e-18---
Showing 1 to 3 of 3 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
KINASE-PSP_CDK1S1301.1e-110.242.2e-50.740.0178.6e-50.0611.1e-6-0.580.440.014
PROGENy: PI3KS1303.3e-100.56-0.952.3e-48.0e-43.4e-42.3e-30.045-0.910.0750.044
HALLMARK_G2M_CHECKPOINTS1306.1e-90.780.0950.0110.0332.8e-55.8e-30.047-0.40.0060.36
HALLMARK_E2F_TARGETSS1306.6e-9-0.920.0210.0210.0358.4e-60.0110.017-0.240.0320.18
PROGENy: MAPKS1307.1e-90.27-0.480.383.4e-55.5e-70.0940.0770.420.0320.14
KINASE-PSP_CDK2S1301.3e-80.610.0360.820.281.7e-50.173.3e-50.630.360.004
HALLMARK_GLYCOLYSISS1301.6e-80.340.0316.8e-33.4e-50.016-0.970.067-0.0290.167.0e-6
PROGENy: EGFRS1301.8e-70.610.380.193.3e-62.4e-40.330.18-0.690.30.012
PROGENy: p53S1302.9e-70.0491.1e-41.6e-32.6e-4-0.720.11-0.940.65-0.191.1e-3
HALLMARK_DNA_REPAIRS1303.7e-70.550.110.532.8e-41.1e-60.0180.5-0.160.240.059
Showing 1 to 10 of 774 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS31S114S130proteinRNASCNVmethylationCCRCCS31S114S130proteinRNASCNVmethylationCOADS31S114S130proteinRNASCNVmethylationGBMS31S114S130proteinRNASCNVmethylationHNSCCS31S114S130proteinRNASCNVmethylationLSCCS31S114S130proteinRNASCNVmethylationLUADS31S114S130proteinRNASCNVmethylationOVS31S114S130proteinRNASCNVmethylationPDACS31S114S130proteinRNASCNVmethylationUCECS31S114S130proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
BAZ1AS1308.5e-11-0.960.41.4e-39.5e-37.5e-54.2e-40.085-0.140.026
CDK7S1304.5e-63.6e-3-0.990.180.22.2e-30.1310.370.612.5e-3
EGFRS1301.0e-5-0.80.0540.0180.785.5e-70.170.140.340.21-0.69
SMG1S1303.1e-50.130.220.860.52.2e-50.0210.190.130.18-0.26
CDK1S1303.7e-5-0.760.790.420.621.3e-55.6e-30.011-0.190.120.06
CDK9S1304.0e-50.170.222.6e-32.1e-30.0310.20.43-0.210.550.46
WEE1S1304.0e-50.530.040.470.198.8e-30.170.037-0.12-1
STK17AS1304.1e-50.250.16-2.9e-44.4e-3-0.870.27-0.950.12
PKMYT1S1309.5e-5-0.530.450.0150.414.2e-40.0141.4e-3-0.63-0.18
MELKS1301.4e-40.93--2.6e-30.40.0580.054--0.12
Showing 1 to 10 of 1614 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HDHD2S130-3.3e-10-0.140.93-0.019-1.2e-5-1.2e-4-8.1e-3-3.2e-30.27-0.27-0.019
LHPPS130-2.5e-8-0.034-0.7-0.1-6.8e-5-4.9e-5-0.017-8.9e-30.9-0.69-0.86
PPM1KS130-2.7e-8-0.05-0.12--5.5e-6-0.035-0.1-0.046-0.71-0.023
PTPN23S130-3.9e-8-0.71-0.056-0.35-0.47-1.5e-4-0.13-3.7e-4-0.96-0.074-5.7e-3
BPNT1S130-1.2e-6-0.12-0.47-0.5-3.0e-4-3.8e-6-0.038-0.140.53-0.35-0.75
MTMR2S130-1.5e-5-0.13-0.93-0.05-2.4e-4-0.06-0.0340.48--0.081-0.5
DUSP22S130-2.1e-5-0.360.47-0.26-0.081-0.026-0.21-0.052--0.015-0.068
PPP1CBS130-2.5e-5-5.7e-3-0.27-1.5e-30.77-5.1e-3-0.290.93-0.580.9-0.017
TNS2S130-2.5e-50.39-0.024-0.28-0.86-0.013-0.066-0.0040.24-0.02-0.02
PLPP3S130-1.4e-40.079-0.17-0.42-1.7e-4-0.017-0.062-0.0470.52-0.13-0.46
Showing 1 to 10 of 720 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.