Protein: ENSP00000246548
Gene: UBA2

LinkedOmicsKB © 2022-2023 Zhang Lab

UBA2:
ubiquitin like modifier activating enzyme 2

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S207EDADQEVSPDRADPE10120296-10380949444-1005889806461461286364811
S229AEARARASNEDGDIK1068031-675611719-4021736753507270276316
S289LDWAEVQSQGEETNA2246---126--------------
T294VQSQGEETNASDQQN4448-44----12655--------
S297QGEETNASDQQNEPQ2188-------73----------
S570AKSITNGSDDGAQPS1044753-3826232922-301956294220329113815
S577SDDGAQPSTSTAQEQ341----108------45----122
T578DDGAQPSTSTAQEQD219--86------------41--
S579DGAQPSTSTAQEQDD1061522-3926626045-7439251219164271315414
T580GAQPSTSTAQEQDDV68118-88--13-54--53----89
Showing 1 to 10 of 15 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S207EDADQEVSPDRADPE-0.2--1.1e-51.7e-5--0.930.91-1.4e-9-0.141.6e-6-0.41
S229AEARARASNEDGDIK0.028-0.62--5.7e-70.016-0.29--0.0570.66
S289LDWAEVQSQGEETNA-----------
T294VQSQGEETNASDQQN-----------
S297QGEETNASDQQNEPQ-----------
S570AKSITNGSDDGAQPS2.1e-4--0.110.042-0.341.9e-8---0.291.6e-3
S577SDDGAQPSTSTAQEQ-----------
T578DDGAQPSTSTAQEQD-----------
S579DGAQPSTSTAQEQDD5.1e-4--0.442.4e-8-0.852.2e-6--0.016-3.0e-4
T580GAQPSTSTAQEQDDV-----------
Showing 1 to 10 of 15 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS207S229S289T294S297S570S577T578S579T580S592S597S598S609S625proteinRNASCNVmethylationCCRCCS207S229S289T294S297S570S577T578S579T580S592S597S598S609S625proteinRNASCNVmethylationCOADS207S229S289T294S297S570S577T578S579T580S592S597S598S609S625proteinRNASCNVmethylationGBMS207S229S289T294S297S570S577T578S579T580S592S597S598S609S625proteinRNASCNVmethylationHNSCCS207S229S289T294S297S570S577T578S579T580S592S597S598S609S625proteinRNASCNVmethylationLSCCS207S229S289T294S297S570S577T578S579T580S592S597S598S609S625proteinRNASCNVmethylationLUADS207S229S289T294S297S570S577T578S579T580S592S597S598S609S625proteinRNASCNVmethylationOVS207S229S289T294S297S570S577T578S579T580S592S597S598S609S625proteinRNASCNVmethylationPDACS207S229S289T294S297S570S577T578S579T580S592S597S598S609S625proteinRNASCNVmethylationUCECS207S229S289T294S297S570S577T578S579T580S592S597S598S609S625proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.