HSPB1: heat shock protein family B (small) member 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2n3j chain A
2n3j chain B
3q9p chain A
3q9q chain A
3q9q chain B
4mjh chain A
4mjh chain B
4mjh chain C
4mjh chain D
6dv5 chain A
6dv5 chain B
6dv5 chain C
6dv5 chain D
6dv5 chain E
6dv5 chain F
6dv5 chain G
6dv5 chain H
6dv5 chain I
6dv5 chain J
6dv5 chain K
6dv5 chain L
6dv5 chain M
6dv5 chain N
6dv5 chain O
6dv5 chain P
6dv5 chain Q
6dv5 chain R
6dv5 chain S
6dv5 chain T
6dv5 chain U
6dv5 chain V
6dv5 chain W
6dv5 chain X
6gjh chain A
6gjh chain B
6gjh chain C
6gjh chain D
6gjh chain E
6gjh chain F
6gjh chain G
6gjh chain H
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S9 TERRVPFS LLRGPSW 8 343 - - 17 16 32 31 72 - 35 21 19 17 - - 12 4 12 7 44 4 S15 FSLLRGPS WDPFRDW 10 1553 122 - 103 80 97 100 99 - 108 62 108 99 110 101 83 19 105 44 95 18 S26 FRDWYPHS RLFDQAF 5 124 - - - - 8 10 46 - - - 5 5 - - 15 2 - - 28 5 S43 PRLPEEWS QWLGGSS 3 46 - - - - - - - - 14 5 5 5 - - - - - - 12 5 S49 WSQWLGGS SWPGYVR 5 125 - - 38 34 - - 18 - 6 3 9 8 5 4 - - - - - - S50 SQWLGGSS WPGYVRP 9 722 38 - 87 65 73 69 26 - 94 54 44 36 33 26 - - 39 16 20 2 Y54 GGSSWPGY VRPLPPA 4 59 - - 4 4 16 20 - - 6 4 - - - - - - 4 1 - - S65 LPPAAIES PAVAAPA 10 1383 6 - 103 80 97 100 80 - 108 62 108 99 110 99 83 19 86 30 95 18 S78 PAYSRALS RQLSSGV 10 394 8 - 38 28 4 5 15 - 63 37 5 4 4 4 14 3 36 13 95 18 S82 RALSRQLS SGVSEIR 10 1367 104 - 66 46 97 100 99 - 95 56 103 94 73 70 83 19 105 44 95 18
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S9 TERRVPFS LLRGPSW -4.1e-4 - - -7.0e-4 - -0.11 - - - - - S15 FSLLRGPS WDPFRDW -1.8e-8 - 5e-20 -7e-17 - -1.6e-5 -0.082 -1.2e-23 -2.0e-5 2.5e-11 -0.034 S26 FRDWYPHS RLFDQAF - - - - - - - - - - - S43 PRLPEEWS QWLGGSS - - - - - - - - - - - S49 WSQWLGGS SWPGYVR 3.8e-7 - 3.8e-7 - - - - - - - - S50 SQWLGGSS WPGYVRP 0.89 - 1.2e-10 -2.8e-6 - -2.8e-3 -0.84 -0.016 - 5.0e-4 - Y54 GGSSWPGY VRPLPPA - - - - - - - - - - - S65 LPPAAIES PAVAAPA -9.2e-4 - 8.2e-8 -1.1e-14 - -2e-14 0.23 -9.5e-4 -1.3e-3 2.2e-3 0.004 S78 PAYSRALS RQLSSGV 0.11 - 1.1e-3 - - -7.9e-8 - - - 0.044 9.7e-4 S82 RALSRQLS SGVSEIR -0.15 - 8.5e-9 -2.1e-21 - -0.087 0.027 -0.28 -1.8e-5 3.5e-4 0.32
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S9
S15
S26
S43
S49
S50
Y54
S65
S78
S82
S83
S86
T91
S98
Y133
S135
Y142
T143
S155
S156
S158
T162
T174
S176
T184
S187
S199
T202
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S9 S15 S26 S43 S49 S50 Y54 S65 S78 S82 S83 S86 T91 S98 Y133 S135 Y142 T143 S155 S156 S158 T162 T174 S176 T184 S187 S199 T202 protein RNA SCNV methylation CCRCC S9 S15 S26 S43 S49 S50 Y54 S65 S78 S82 S83 S86 T91 S98 Y133 S135 Y142 T143 S155 S156 S158 T162 T174 S176 T184 S187 S199 T202 protein RNA SCNV methylation COAD S9 S15 S26 S43 S49 S50 Y54 S65 S78 S82 S83 S86 T91 S98 Y133 S135 Y142 T143 S155 S156 S158 T162 T174 S176 T184 S187 S199 T202 protein RNA SCNV methylation GBM S9 S15 S26 S43 S49 S50 Y54 S65 S78 S82 S83 S86 T91 S98 Y133 S135 Y142 T143 S155 S156 S158 T162 T174 S176 T184 S187 S199 T202 protein RNA SCNV methylation HNSCC S9 S15 S26 S43 S49 S50 Y54 S65 S78 S82 S83 S86 T91 S98 Y133 S135 Y142 T143 S155 S156 S158 T162 T174 S176 T184 S187 S199 T202 protein RNA SCNV methylation LSCC S9 S15 S26 S43 S49 S50 Y54 S65 S78 S82 S83 S86 T91 S98 Y133 S135 Y142 T143 S155 S156 S158 T162 T174 S176 T184 S187 S199 T202 protein RNA SCNV methylation LUAD S9 S15 S26 S43 S49 S50 Y54 S65 S78 S82 S83 S86 T91 S98 Y133 S135 Y142 T143 S155 S156 S158 T162 T174 S176 T184 S187 S199 T202 protein RNA SCNV methylation OV S9 S15 S26 S43 S49 S50 Y54 S65 S78 S82 S83 S86 T91 S98 Y133 S135 Y142 T143 S155 S156 S158 T162 T174 S176 T184 S187 S199 T202 protein RNA SCNV methylation PDAC S9 S15 S26 S43 S49 S50 Y54 S65 S78 S82 S83 S86 T91 S98 Y133 S135 Y142 T143 S155 S156 S158 T162 T174 S176 T184 S187 S199 T202 protein RNA SCNV methylation UCEC S9 S15 S26 S43 S49 S50 Y54 S65 S78 S82 S83 S86 T91 S98 Y133 S135 Y142 T143 S155 S156 S158 T162 T174 S176 T184 S187 S199 T202 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S9
S15
S26
S43
S49
S50
Y54
S65
S78
S82
S83
S86
T91
S98
Y133
S135
Y142
T143
S155
S156
S158
T162
T174
S176
T184
S187
S199
T202
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S9
S15
S26
S43
S49
S50
Y54
S65
S78
S82
S83
S86
T91
S98
Y133
S135
Y142
T143
S155
S156
S158
T162
T174
S176
T184
S187
S199
T202
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.