Protein: ENSP00000249636
Gene: PIAS1

LinkedOmicsKB © 2022-2023 Zhang Lab

PIAS1:
protein inhibitor of activated STAT 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

Loading, please wait
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S466VIDLTIDSSSDEEEE22718-54----------------
S467IDLTIDSSSDEEEEE22718-54----------------
S468DLTIDSSSDEEEEEP22718-54----------------
T480EEPSAKRTCPSLSPT18------------44------
S483SAKRTCPSLSPTSPL9869105-33798281-7040989044--9638679
S485KRTCPSLSPTSPLNN1072824-3322675944-80473934252420695415216
T487TCPSLSPTSPLNNKG71758-1714----135494444--836-
S488CPSLSPTSPLNNKGI1069479-44504945-53287873121146136526544
S503LSLPHQASPVSRTPS101525122-9976979990-10862103941101018319105449518
S506PHQASPVSRTPSLPA599--3131--8-645554------
Showing 1 to 10 of 17 rows
1025
rows per page

Tumor and normal comparison

Loading, please wait
Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S466VIDLTIDSSSDEEEE-----------
S467IDLTIDSSSDEEEEE-----------
S468DLTIDSSSDEEEEEP-----------
T480EEPSAKRTCPSLSPT-----------
S483SAKRTCPSLSPTSPL-1.6e-6--0.64-0.011-7.6e-14---3e-7-
S485KRTCPSLSPTSPLNN4.9e-10-0.0643.2e-5-9.1e-101.2e-50.021--9.9e-60.039
T487TCPSLSPTSPLNNKG-1.1e-4------1.1e-4----
S488CPSLSPTSPLNNKGI-1.1e-3---1--0.22-0.043--0.077-0.021-
S503LSLPHQASPVSRTPS0.016--5.9e-68.8e-9--3.7e-30.720.110.341.3e-70.77
S506PHQASPVSRTPSLPA0.097-0.097--------
Showing 1 to 10 of 17 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

Loading, please wait
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS466S467S468T480S483S485T487S488S503S506T508S510T516Y518S624S626S634proteinRNASCNVmethylationCCRCCS466S467S468T480S483S485T487S488S503S506T508S510T516Y518S624S626S634proteinRNASCNVmethylationCOADS466S467S468T480S483S485T487S488S503S506T508S510T516Y518S624S626S634proteinRNASCNVmethylationGBMS466S467S468T480S483S485T487S488S503S506T508S510T516Y518S624S626S634proteinRNASCNVmethylationHNSCCS466S467S468T480S483S485T487S488S503S506T508S510T516Y518S624S626S634proteinRNASCNVmethylationLSCCS466S467S468T480S483S485T487S488S503S506T508S510T516Y518S624S626S634proteinRNASCNVmethylationLUADS466S467S468T480S483S485T487S488S503S506T508S510T516Y518S624S626S634proteinRNASCNVmethylationOVS466S467S468T480S483S485T487S488S503S506T508S510T516Y518S624S626S634proteinRNASCNVmethylationPDACS466S467S468T480S483S485T487S488S503S506T508S510T516Y518S624S626S634proteinRNASCNVmethylationUCECS466S467S468T480S483S485T487S488S503S506T508S510T516Y518S624S626S634proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

Loading, please wait
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

Loading, please wait
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.